| + |
TYSND1 | up-regulates activity 
cleavage
|
ACOX1 |
0.682 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-261057 |
|
|
in vitro |
|
| pmid |
sentence |
| 17255948 |
Here, we demonstrate that Tysnd1, a previously uncharacterized protein, is responsible both for the removal of the leader peptide from PTS2 proteins and for the specific processing of PTS1 proteins. All of the identified Tysnd1 substrates catalyze peroxisomal β-oxidation. In vitro cleavage of Acox1, Scp2 and prethiolase by recombinant Tysnd1. |
|
| Publications: |
1 |
Organism: |
In Vitro |
| + |
SIRT5 | down-regulates activity 
catalytic activity
|
ACOX1 |
0.263 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-261210 |
|
|
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 29491006 |
SIRT5‐mediated desuccinylation inhibits ACOX1 activity by suppressing its active dimer formation. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
ACOX1 | down-regulates quantity by destabilization
binding
|
TP73 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-261056 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 31401980 |
Downregulation of ACOX1 increased p73, but not p53, expression. p73 expression was critical for apoptosis induction induced by ACOX1 downregulation. ACOX1 reduced p73 expression by destabilizing p73 protein. We also found that ACOX1 interacted with p73 protein |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
3.0
ACOX1
- 
- 