Relation Results

Summary

Name ACOX1
Full Name Peroxisomal acyl-coenzyme A oxidase 1
Synonyms AOX, Palmitoyl-CoA oxidase, Straight-chain acyl-CoA oxidase, SCOX | ACOX
Primary ID Q15067
Links - -
Type protein
Relations 3
Function Catalyzes the desaturation of acyl-CoAs to 2-trans-enoyl-CoAs. First enzyme of the fatty acid beta-oxidation pathway.

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Type: Score: Layout: SPV 
0.20.2610.691ACOX1TP73SIRT5TYSND1

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Relations
Regulator
Mechanism
target
score ℹ
+ ACOX1down-regulates quantity by destabilization img/direct_inhibition.png binding TP73 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-261056 Homo sapiens
pmid sentence
Downregulation of ACOX1 increased p73, but not p53, expression. p73 expression was critical for apoptosis induction induced by ACOX1 downregulation. ACOX1 reduced p73 expression by destabilizing p73 protein. We also found that ACOX1 interacted with p73 protein
Publications: 1 Organism: Homo Sapiens
+ SIRT5down-regulates activity img/direct_inhibition.png catalytic activity ACOX1 0.261
Identifier Residue Sequence Organism Cell Line
SIGNOR-261210 Homo sapiens HEK-293 Cell
pmid sentence
SIRT5‐mediated desuccinylation inhibits ACOX1 activity by suppressing its active dimer formation.
Publications: 1 Organism: Homo Sapiens
+ TYSND1up-regulates activity img/direct-activation.png cleavage ACOX1 0.691
Identifier Residue Sequence Organism Cell Line
SIGNOR-261057 in vitro
pmid sentence
Here, we demonstrate that Tysnd1, a previously uncharacterized protein, is responsible both for the removal of the leader peptide from PTS2 proteins and for the specific processing of PTS1 proteins. All of the identified Tysnd1 substrates catalyze peroxisomal β-oxidation. In vitro cleavage of Acox1, Scp2 and prethiolase by recombinant Tysnd1.
Publications: 1 Organism: In Vitro
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