| + |
AURKA | down-regulates activity 
phosphorylation
|
TP73 |
0.451 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-278263 |
Ser235 |
DPVTGRQsVVVPYEP |
Homo sapiens |
|
| pmid |
sentence |
| 22340593 |
Aurora-A inhibits p73 and p53 transactivation functions through a common molecular mechanism.|We report that Aurora-A phosphorylation of p73 at serine235 abrogates its transactivation function and causes cytoplasmic sequestration in a complex with the chaperon protein mortalin. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
PRKCD | up-regulates 
phosphorylation
|
TP73 |
0.306 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-90279 |
Ser289 |
GQVLGRRsFEGRICA |
Homo sapiens |
|
| pmid |
sentence |
| 12097319 |
The results show that pkcdeltacf phosphorylates the p73beta transactivation and dna-binding domains. pkcdeltacf-mediated phosphorylation of p73beta is associated with accumulation of p73beta and induction of p73beta-mediated transactivation. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
PRKCA | up-regulates activity
phosphorylation
|
TP73 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-276235 |
Ser388 |
VPQPLVDsYRQQQQL |
Homo sapiens |
|
| pmid |
sentence |
| 19158275 |
Here, we report that p73 is able to induce cell cycle arrest independently of its amino-terminal transactivation domain, whereas this domain is crucial for p73 proapoptotic functions. its activity is regulated throughout the cell cycle and modified by protein kinase C-dependent phosphorylation at serine residue 388. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
PRKCB | up-regulates activity
phosphorylation
|
TP73 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-276234 |
Ser388 |
VPQPLVDsYRQQQQL |
Homo sapiens |
|
| pmid |
sentence |
| 19158275 |
Here, we report that p73 is able to induce cell cycle arrest independently of its amino-terminal transactivation domain, whereas this domain is crucial for p73 proapoptotic functions. its activity is regulated throughout the cell cycle and modified by protein kinase C-dependent phosphorylation at serine residue 388. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
CHEK1 | up-regulates
phosphorylation
|
TP73 |
0.536 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-118913 |
Ser47 |
EVVGGTDsSMDVFHL |
Homo sapiens |
|
| pmid |
sentence |
| 14585975 |
We found that endogenous p73alpha is serine phosphorylated by endogenous chk1 upon dna damage, which is a mechanism required for the apoptotic-inducing function of p73alpha. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
PLK2 | down-regulates activity
phosphorylation
|
TP73 |
0.276 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-278218 |
Ser48 |
VVGGTDSsMDVFHLE |
Homo sapiens |
|
| pmid |
sentence |
| 26625870 |
PLK2 inhibits TAp73 translocation to the nucleus.|PLK2 phosphorylated TAp73 at residue Ser48 within the TA domain; phosphorylation of TAp73 was abolished by mutating this residue. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
PLK1 | down-regulates
phosphorylation
|
TP73 |
0.509 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-178253 |
Thr27 |
SSLEPDStYFDLPQS |
Homo sapiens |
|
| pmid |
sentence |
| 18418051 |
P73-mediated transcriptional activity is negatively regulated by polo-like kinase 1. tap73 is phosphorylated by this kinase on threonine-27 (thr-27) within the ta domain. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
CDK1 | down-regulates activity
phosphorylation
|
TP73 |
0.553 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-99742 |
Thr86 |
AASASPYtPEHAASV |
Homo sapiens |
|
| pmid |
sentence |
| 12676926 |
Cyclin-dependent kinases phosphorylate p73 at threonine 86 in a cell cycle-dependent manner and negatively regulate p73.Furthermore, cyclin a/cdk1/2, cyclin b/cdk1/2, and cyclin e/cdk2 complexes can phosphorylate multiple p73 isoforms in vitro at threonine 86. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
CyclinB/CDK1 | down-regulates
phosphorylation
|
TP73 |
0.472 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-216849 |
Thr86 |
AASASPYtPEHAASV |
Homo sapiens |
|
| pmid |
sentence |
| 12676926 |
Cyclin-dependent kinases phosphorylate p73 at threonine 86 in a cell cycle-dependent manner and negatively regulate p73.Furthermore, cyclin a/cdk1/2, cyclin b/cdk1/2, and cyclin e/cdk2 complexes can phosphorylate multiple p73 isoforms in vitro at threonine 86. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
CyclinE/CDK2 | down-regulates
phosphorylation
|
TP73 |
0.533 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-216702 |
Thr86 |
AASASPYtPEHAASV |
Homo sapiens |
|
| pmid |
sentence |
| 12676926 |
Cyclin-dependent kinases phosphorylate p73 at threonine 86 in a cell cycle-dependent manner and negatively regulate p73.Furthermore, cyclin a/cdk1/2, cyclin b/cdk1/2, and cyclin e/cdk2 complexes can phosphorylate multiple p73 isoforms in vitro at threonine 86. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
CDK2 | down-regulates activity
phosphorylation
|
TP73 |
0.572 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-99746 |
Thr86 |
AASASPYtPEHAASV |
Homo sapiens |
|
| pmid |
sentence |
| 12676926 |
Cyclin-dependent kinases phosphorylate p73 at threonine 86 in a cell cycle-dependent manner and negatively regulate p73.Furthermore, cyclin a/cdk1/2, cyclin b/cdk1/2, and cyclin e/cdk2 complexes can phosphorylate multiple p73 isoforms in vitro at threonine 86. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
ABL1 | up-regulates
phosphorylation
|
TP73 |
0.755 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-68931 |
Tyr99 |
SVPTHSPyAQPSSTF |
Homo sapiens |
|
| pmid |
sentence |
| 10391251 |
C-abl phosphorylates p73 on a tyrosine residue at position 99 both in vitro and in cells that have been exposed to ionizing radiation. Our results show that c-abl stimulates p73-mediated transactivation and apoptosis. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
WWP2 | down-regulates quantity by destabilization
polyubiquitination
|
TP73 |
0.283 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-272233 |
|
|
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 25071155 |
WWP2 ubiquitinates p73 and controls its protein stability. In our study, we identified WWP2, an E3 ligase, as a novel p73-associated protein that ubiquitinates and degrades p73. In contrast, WWP2 heterodimerizes with another E3 ligase, WWP1, which specifically ubiquitinates and degrades ΔNp73. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
Nutlin-3 | up-regulates
|
TP73 |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-255472 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 17700533 |
These results provide the first evidence that Nutlin-3 disrupts endogenous p73-HDM2 interaction and enhances the stability and proapoptotic activities of p73 and thus, provides a rationale for the use of Nutlin-3 in the large number of human tumors in which p53 is inactivated. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
TP73 | up-regulates quantity by expression 
transcriptional regulation
|
PMAIP1 |
0.323 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-255469 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 17700533 |
Dissociation of p73 and HDM2 leads to increased p73 transcriptional activity with upregulation of p73 target genes noxa, puma and p21, as well as enhanced apoptosis. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
RPL11 | up-regulates
binding
|
TP73 |
0.36 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-205514 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 25301064 |
We report that rpl5 and rpl11 can also enhance the transcriptional activity of a p53 homolog tap73 |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
WWP1 | down-regulates quantity by destabilization
polyubiquitination
|
TP73 |
0.283 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-272232 |
|
|
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 25071155 |
WWP1 in complex with WWP2 specifically regulates ΔNp73. In our study, we identified WWP2, an E3 ligase, as a novel p73-associated protein that ubiquitinates and degrades p73. In contrast, WWP2 heterodimerizes with another E3 ligase, WWP1, which specifically ubiquitinates and degrades ΔNp73. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
ACOX1 | down-regulates quantity by destabilization
binding
|
TP73 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-261056 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 31401980 |
Downregulation of ACOX1 increased p73, but not p53, expression. p73 expression was critical for apoptosis induction induced by ACOX1 downregulation. ACOX1 reduced p73 expression by destabilizing p73 protein. We also found that ACOX1 interacted with p73 protein |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
RPL5 | up-regulates
binding
|
TP73 |
0.341 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-205517 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 25301064 |
We report that rpl5 and rpl11 can also enhance the transcriptional activity of a p53 homolog tap73 |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
TP73 | up-regulates
|
Apoptosis |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-255473 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 17700533 |
Like p53, its homolog p73 transactivates proapoptotic genes and induces cell death. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
HECW2 | up-regulates quantity by stabilization
ubiquitination
|
TP73 |
0.37 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-269457 |
|
|
Chlorocebus aethiops |
COS-7 Cell |
| pmid |
sentence |
| 12890487 |
P73 was efficiently ubiquitinated but stabilized in a NEDL2-dependent manner. Accordingly, p73 decayed at faster rates in the absence of NEDL2 than in its presence. Consistent with the NEDL2-mediated stabilization of p73, NEDL2 enhanced the p73-dependent transcriptional activation. Thus, our results suggest that NEDL2 activates the function of p73 by increasing its stability. |
|
| Publications: |
1 |
Organism: |
Chlorocebus Aethiops |
| + |
MAPK8 | up-regulates activity
phosphorylation
|
TP73 |
0.421 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-279219 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 23516355 |
Therefore, it is likely that p73 recruitment to the \u0394Np73 promoter is mediated by its JNK-1-dependent phosphorylation. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
YAP/TAZ | up-regulates activity
binding
|
TP73 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-277663 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 25287865 |
The WW domains are essential for YAP-induced cell proliferation (261) and mediate binding of YAP/TAZ to PPxY motif-containing transcription factors such as RUNX, p73, and the cytoplasmic domain of ERBB4 or with the transcriptional cofactor WBP2 |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-277668 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 25287865 |
The WW domains are essential for YAP-induced cell proliferation (261) and mediate binding of YAP/TAZ to PPxY motif-containing transcription factors such as RUNX, p73, and the cytoplasmic domain of ERBB4 or with the transcriptional cofactor WBP2 |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| + |
Cullin 1-RBX1-Skp1 | down-regulates quantity by destabilization
polyubiquitination
|
TP73 |
0.282 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-271877 |
|
|
Homo sapiens |
SK-N-SH Cell |
| pmid |
sentence |
| 19581926 |
The F-box protein FBXO45 promotes the proteasome-dependent degradation of p73.Importantly, SCFFBXO45 ubiquitylates p73 both in vivo and in vitro. Expression of Cul1 dominant negative mutant, but not Cul2, Cul3, Cul4 and Cul5 dominant negative mutants, increased p73 levels (Figure 1c) to an extent similar to that observed in the ts41 cell line at not permissive temperature, suggesting that a Cul1-associated activity is required for p73 protein stability. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
CHUK | up-regulates activity
phosphorylation
|
TP73 |
0.335 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-279697 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 22084676 |
IKK-alpha had an ability to stabilize p73 by inhibiting its polyubiquitination, and enhanced p73 mediated transcriptional activation as well as proapoptotic activity.|In addition, IKK-alpha phosphorylated the NH 2 -terminal portion of p73 and a kinase deficient mutant form of IKK-alpha had undetectable effect on p73. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
YAP1 | up-regulates
binding
|
TP73 |
0.714 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-175934 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 21808241 |
Yap also interacts with p73, a p53 family pro-apoptotic transcription factor, to induce expression of genes such as bax, puma and pml. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
TP73 | up-regulates quantity by expression
transcriptional regulation
|
CDKN1A |
0.372 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-255468 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 17700533 |
Dissociation of p73 and HDM2 leads to increased p73 transcriptional activity with upregulation of p73 target genes noxa, puma and p21, as well as enhanced apoptosis. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
TP73 | up-regulates quantity by expression
transcriptional regulation
|
BBC3 |
0.472 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-255467 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 17700533 |
Dissociation of p73 and HDM2 leads to increased p73 transcriptional activity with upregulation of p73 target genes noxa, puma and p21, as well as enhanced apoptosis. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
FBXO45 | down-regulates quantity by destabilization
binding
|
TP73 |
0.596 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-271876 |
|
|
Homo sapiens |
SK-N-SH Cell |
| pmid |
sentence |
| 19581926 |
The F-box protein FBXO45 promotes the proteasome-dependent degradation of p73.Importantly, SCFFBXO45 ubiquitylates p73 both in vivo and in vitro. Expression of Cul1 dominant negative mutant, but not Cul2, Cul3, Cul4 and Cul5 dominant negative mutants, increased p73 levels (Figure 1c) to an extent similar to that observed in the ts41 cell line at not permissive temperature, suggesting that a Cul1-associated activity is required for p73 protein stability. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
MDM2 | down-regulates activity
binding
|
TP73 |
0.835 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-255470 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 17700533 |
Since HDM2, a key negative regulator of p53, also binds to and inhibits p73, we asked whether p73 could mediate Nutlin-3-induced apoptosis. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
TP73 | up-regulates
|
Cell_death |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-256665 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 17700533 |
Like p53, its homolog p73 transactivates proapoptotic genes and induces cell death. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
ITCH | down-regulates quantity by destabilization
ubiquitination
|
TP73 |
0.563 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-278699 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 21093410 |
Collectively, our present findings suggest that MDM2 promotes Itch-mediated degradation of p73 through the interaction with Itch in HeLa cells |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
PLK3 | down-regulates activity
phosphorylation
|
TP73 |
0.408 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-279647 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 19490146 |
In this study, we found that Plk3 inhibits pro-apoptotic activity of p73 through physical interaction and phosphorylation.|Plk3 inhibits pro-apoptotic activity of p73 through physical interaction and phosphorylation. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
4.0
TP73
- 
- 