| + |
MYC | up-regulates quantity by expression 
transcriptional regulation
|
SURF1 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254615 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 10858544 |
We show that although the Surf-1/Surf-2 promoter does not contain Myc binding sites (E-boxes), Myc over-expression, or the activation of a Myc-oestrogen receptor fusion protein, activates transcription in the Surf-1 direction and that this response to Myc requires a functional YY1 binding site. Our data suggest that the MAP kinase cascade is required for the stimulation of Surf-1 promoter activity and that the Myc-YY1 interaction mediates this response. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
YY1 | up-regulates quantity by expression
transcriptional regulation
|
SURF1 |
0.316 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254614 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 10858544 |
We show that although the Surf-1/Surf-2 promoter does not contain Myc binding sites (E-boxes), Myc over-expression, or the activation of a Myc-oestrogen receptor fusion protein, activates transcription in the Surf-1 direction and that this response to Myc requires a functional YY1 binding site. Our data suggest that the MAP kinase cascade is required for the stimulation of Surf-1 promoter activity and that the Myc-YY1 interaction mediates this response. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
3.0
SURF1
- 
- 