| + |
CSNK2A1 | up-regulates 
phosphorylation
|
YY1 |
0.286 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-200083 |
Ser118 |
EVVGGDDsDGLRAED |
Homo sapiens |
|
| pmid |
sentence |
| 23226345 |
More recently, we identified and mapped multiple phosphorylation sites in yy1, including, threonine 39, serine 118, serine 247, threonine 348 and threonine 378. The first kinase proven to phosphorylate yy1 in vivo was plk1, which phosphorylates threonine 39 during g2/m stage of the cell cycle [25]. Ck2_ is another kinase identified as constitutively phosphorylating yy1 at serine 118. This modification protects yy1 cleavage by caspase 7 during apoptosis |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
AURKB | up-regulates
phosphorylation
|
YY1 |
0.368 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-200075 |
Ser180 |
KKGGGKKsGKKSYLS |
Homo sapiens |
|
| pmid |
sentence |
| 23226345 |
Aurora b kinase phosphorylates yy1 on serine 184 and to a lesser extent serine 180 at the g2/m stage of the cell cycle (fig. 7). We show that yy1 is rapidly dephosphorylated as the cells exit mitosis, likely by pp1. Also, our data indicates that phosphorylation at serine 180 and serine 184 can affect the dna binding activity of yy1 |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-200079 |
Ser184 |
GKKSGKKsYLSGGAG |
Homo sapiens |
|
| pmid |
sentence |
| 23226345 |
Aurora b kinase phosphorylates yy1 on serine 184 and to a lesser extent serine 180 at the g2/m stage of the cell cycle (fig. 7). We show that yy1 is rapidly dephosphorylated as the cells exit mitosis, likely by pp1. Also, our data indicates that phosphorylation at serine 180 and serine 184 can affect the dna binding activity of yy1 |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| + |
PLK1 | up-regulates
phosphorylation
|
YY1 |
0.391 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-200087 |
Thr39 |
PVETIETtVVGEEEE |
Homo sapiens |
|
| pmid |
sentence |
| 23226345 |
More recently, we identified and mapped multiple phosphorylation sites in yy1, including, threonine 39, serine 118, serine 247, threonine 348 and threonine 378. The first kinase proven to phosphorylate yy1 in vivo was plk1, which phosphorylates threonine 39 during g2/m stage of the cell cycle [25]. Ck2_ is another kinase identified as constitutively phosphorylating yy1 at serine 118. This modification protects yy1 cleavage by caspase 7 during apoptosis |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
LYN | down-regulates activity 
phosphorylation
|
YY1 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-276929 |
Tyr254 |
SPPDYSEyMTGKKLP |
Homo sapiens |
HEK-293T Cell |
| pmid |
sentence |
| 26198631 |
In the case of Lyn overexpression, single mutations at either tyrosine 8, 254, or 383 severely reduced Lyn-mediated YY1 phosphorylation, suggesting that these three sites may be targets of Lyn in vivo (Fig. 3, A and B). |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-276928 |
Tyr383 |
IHTGDRPyVCPFDGC |
Homo sapiens |
HEK-293T Cell |
| pmid |
sentence |
| 26198631 |
In the case of Lyn overexpression, single mutations at either tyrosine 8, 254, or 383 severely reduced Lyn-mediated YY1 phosphorylation, suggesting that these three sites may be targets of Lyn in vivo (Fig. 3, A and B). |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-276930 |
Tyr8 |
MASGDTLyIATDGSE |
Homo sapiens |
HEK-293T Cell |
| pmid |
sentence |
| 26198631 |
In the case of Lyn overexpression, single mutations at either tyrosine 8, 254, or 383 severely reduced Lyn-mediated YY1 phosphorylation, suggesting that these three sites may be targets of Lyn in vivo (Fig. 3, A and B). |
|
| Publications: |
3 |
Organism: |
Homo Sapiens |
| + |
YY1 | up-regulates quantity by expression
|
Polycomb repressive complex 2 |
0.602 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-253595 |
|
|
|
|
| pmid |
sentence |
| 17158804 |
YY1 REPO domain is necessary and sufficient for PcG transcriptional repression, Polycomb recruitment to DNA, and methylation of histone H3 on lysine 27 |
|
| Publications: |
1 |
| + |
YY1 | up-regulates quantity by expression 
transcriptional regulation
|
HSPA5 |
0.304 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-255620 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 15899857 |
YY1, a constitutively expressed multifunctional transcription factor, activates the Grp78 promoter only under ER stress conditions. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
MYC | down-regulates activity
binding
|
YY1 |
0.545 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-268795 |
|
|
Mus musculus |
NIH-3T3 Cell |
| pmid |
sentence |
| 8266081 |
Inhibition of transcriptional regulator Yin-Yang-1 by association with c-Myc.Yin-Yang-1 (YY1) regulates the transcription of many genes, including the oncogenes c-fos and c-myc. Depending on the context, YY1 acts as a transcriptional repressor, a transcriptional activator, or a transcriptional initiator. In cotransfections, c-Myc inhibits both the repressor and the activator functions of YY1, which suggests that one way c-Myc acts is by modulating the activity of YY1. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| Pathways: | NOTCH Signaling |
| + |
HDAC3 | down-regulates activity
deacetylation
|
YY1 |
0.6 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-268837 |
|
|
in vitro |
|
| pmid |
sentence |
| 11486036 |
Previous studies have established that YY1 interacts with histone acetyltransferases p300 and CREB-binding protein (CBP) and histone deacetylase 1 (HDAC1), HDAC2, and HDAC3. Here, we present evidence that the activity of YY1 is regulated through acetylation by p300 and PCAF and through deacetylation by HDACs. YY1 was acetylated in two regions: both p300 and PCAF acetylated the central glycine-lysine-rich domain of residues 170 to 200, and PCAF also acetylated YY1 at the C-terminal DNA-binding zinc finger domain. Acetylation of the central region was required for the full transcriptional repressor activity of YY1 and targeted YY1 for active deacetylation by HDACs. |
|
| Publications: |
1 |
Organism: |
In Vitro |
| + |
YY1 | up-regulates quantity by expression
transcriptional regulation
|
SURF1 |
0.309 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254614 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 10858544 |
We show that although the Surf-1/Surf-2 promoter does not contain Myc binding sites (E-boxes), Myc over-expression, or the activation of a Myc-oestrogen receptor fusion protein, activates transcription in the Surf-1 direction and that this response to Myc requires a functional YY1 binding site. Our data suggest that the MAP kinase cascade is required for the stimulation of Surf-1 promoter activity and that the Myc-YY1 interaction mediates this response. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
CBP/p300 | up-regulates activity
acetylation
|
YY1 |
0.652 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-268834 |
|
|
in vitro |
|
| pmid |
sentence |
| 11486036 |
Previous studies have established that YY1 interacts with histone acetyltransferases p300 and CREB-binding protein (CBP) and histone deacetylase 1 (HDAC1), HDAC2, and HDAC3. Here, we present evidence that the activity of YY1 is regulated through acetylation by p300 and PCAF and through deacetylation by HDACs. YY1 was acetylated in two regions: both p300 and PCAF acetylated the central glycine-lysine-rich domain of residues 170 to 200, and PCAF also acetylated YY1 at the C-terminal DNA-binding zinc finger domain. Acetylation of the central region was required for the full transcriptional repressor activity of YY1 and targeted YY1 for active deacetylation by HDACs. |
|
| Publications: |
1 |
Organism: |
In Vitro |
| + |
YY1 | form complex 
binding
|
INO80 complex |
0.554 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-270849 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 25016522 |
Here, we have systematically investigated the involvement of the catalytic subunit of the human INO80 complex during unchallenged replication and under replication stress by following the effects of its depletion on cell survival, S-phase checkpoint activation, the fate of individual replication forks, and the consequences of fork collapse. We report that INO80 was specifically needed for efficient replication elongation, while it was not required for initiation of replication. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
YY1 | down-regulates quantity by repression
transcriptional regulation
|
TNFRSF10B |
0.403 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-268793 |
|
|
Homo sapiens |
Melanoma Cell |
| pmid |
sentence |
| 34589486 |
Depletion of FKBP51 impairs the acetylation status of YY1 and interferes with its binding on the DR5 promoter. The lack of the repressor activity of YY1 increases DR5 transcription and sensitizes melanoma cell to TRAIL-induced apoptosis. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
SRC | down-regulates activity
phosphorylation
|
YY1 |
0.284 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-276940 |
|
|
Homo sapiens |
HEK-293T Cell |
| pmid |
sentence |
| 26198631 |
YY1 phosphorylation is mediated by Src family kinases. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
YY1 | down-regulates activity
binding
|
NOTCH |
0.622 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254305 |
|
|
Homo sapiens |
K-562 Cell |
| pmid |
sentence |
| 12913000 |
Taken together, these results indicate that transcription factor YY1 may modulate Notch signaling via association with the high molecular weight Notch complex [..] both YY1 and N1IC were present in a large complex of the nucleus to suppress the luciferase reporter activity transactivated by Notch signaling. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
YY1 | up-regulates quantity by expression
transcriptional regulation
|
COX7C |
0.256 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-255617 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 9092564 |
Mutation of both YY1 sites eliminates most of the promoter activity. Mutation at the upstream YY1 site significantly reduces the efficiency of transcript initiation at the major start site and thus plays the dominant role in COX7C regulation. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
YY1 | up-regulates quantity by expression
transcriptional regulation
|
HSD3B2 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-255619 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 15291746 |
These results designate YY1 as the factor responsible for the intron 1-mediated boost of the HSD3B2 gene basal promoter activity. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
YY1 | down-regulates activity
binding
|
NOTCH1 |
0.622 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-251654 |
|
|
Homo sapiens |
K-562 Cell |
| pmid |
sentence |
| 12913000 |
Taken together, these results indicate that transcription factor YY1 may modulate Notch signaling via association with the high molecular weight Notch complex [..] both YY1 and N1IC were present in a large complex of the nucleus to suppress the luciferase reporter activity transactivated by Notch signaling. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | NOTCH Signaling |
| + |
YY1 | up-regulates quantity by expression
transcriptional regulation
|
FCER1A |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254290 |
|
|
Homo sapiens |
KU-812 Cell |
| pmid |
sentence |
| 11971001 |
Transcriptional regulation of the gene-encoding human Fc epsilon RI alpha-chain was analyzed in detail. EMSA revealed that either YY1 or PU.1 bound to the region close to that recognized by Elf-1. The alpha-chain promoter activity was up-regulated approximately 2-fold by exogenously expressed YY1 or PU.1 and approximately 7-fold by GATA-1, respectively, in KU812 cells |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
FKBP5 | up-regulates activity
|
YY1 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-268792 |
|
|
Homo sapiens |
Melanoma Cell |
| pmid |
sentence |
| 34589486 |
FKBP51 Affects the Binding of YY1 Repressor to DR5 Gene. These results suggest that reduced YY1 DNA-binding activity in FKBP51-silenced cells corresponds to reduced YY1 acetylation. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
YES1 | down-regulates activity
phosphorylation
|
YY1 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-276941 |
|
|
Homo sapiens |
HEK-293T Cell |
| pmid |
sentence |
| 26198631 |
YY1 phosphorylation is mediated by Src family kinases. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
YY1 | up-regulates quantity by expression
transcriptional regulation
|
ATP6V1A |
0.325 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-260635 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 28592880 |
We investigated the relationship between transcription factor YY1 and ATP6V1A, and found that mRNA expression of YY1 had significant correlation with that of ATP6V1A. To validate that YY1 transcriptionally regulates ATP6V1A, we discovered that the ATP6V1A core promoter region contains three YY1 binding sites. Moreover, RNAi-mediated knockdown of YY1 in GC cells significantly decreased ATP6V1A mRNA and protein expression, while YY1 overexpression increased ATP6V1A expression level. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
YY1 | down-regulates quantity by repression 
transcriptional regulation
|
ACTC1 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-255616 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 9171244 |
Expression of YY1 inhibited cardiac alpha-actin promoter activity, whereas coexpression of Nkx-2.5 and SRF was able to partially reverse YY1 repression. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
SMURF2 | down-regulates quantity by destabilization
ubiquitination
|
YY1 |
0.365 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-278544 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 24803334 |
In addition, Smurf2 decreased the protein half-life and transcriptional activity of YY1.|Wild type Smurf2, but not the E3 ubiquitin ligase defective mutant, increased the poly-ubiquitination of YY1. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
YY1 | up-regulates quantity by expression
transcriptional regulation
|
ATP2C1 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-255193 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 15955096 |
when Sp1 or YY1 was overexpressed in keratinocytes, an obvious increase in ATP2C1 promoter activity was observed, which was in contrast with the case where a mutant promoter lacking the binding sites for Sp1 and YY1 was used as the reporter. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
YY1 | up-regulates quantity by expression
transcriptional regulation
|
GDAP1 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-255618 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 19720140 |
Overexpression of YY1 activated the GDAP1 promoter in a reporter gene system as well as increased the level of endogenous mRNA. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
YY1 | form complex
binding
|
SUZ12/EZH2/YY1 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-235580 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 20887952 |
TNF-activated p38a kinase promotes the interaction between YY1 and PRC2, via threonine 372 phosphorylation of EZH2, the enzy- matic subunit of the complex, leading to the for- mation of repressive chromatin on Pax7 promoter. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
HDAC1 | down-regulates activity
deacetylation
|
YY1 |
0.797 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-268835 |
|
|
in vitro |
|
| pmid |
sentence |
| 11486036 |
Previous studies have established that YY1 interacts with histone acetyltransferases p300 and CREB-binding protein (CBP) and histone deacetylase 1 (HDAC1), HDAC2, and HDAC3. Here, we present evidence that the activity of YY1 is regulated through acetylation by p300 and PCAF and through deacetylation by HDACs. YY1 was acetylated in two regions: both p300 and PCAF acetylated the central glycine-lysine-rich domain of residues 170 to 200, and PCAF also acetylated YY1 at the C-terminal DNA-binding zinc finger domain. Acetylation of the central region was required for the full transcriptional repressor activity of YY1 and targeted YY1 for active deacetylation by HDACs. |
|
| Publications: |
1 |
Organism: |
In Vitro |
| + |
HDAC2 | down-regulates activity
deacetylation
|
YY1 |
0.769 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-268836 |
|
|
in vitro |
|
| pmid |
sentence |
| 11486036 |
Previous studies have established that YY1 interacts with histone acetyltransferases p300 and CREB-binding protein (CBP) and histone deacetylase 1 (HDAC1), HDAC2, and HDAC3. Here, we present evidence that the activity of YY1 is regulated through acetylation by p300 and PCAF and through deacetylation by HDACs. YY1 was acetylated in two regions: both p300 and PCAF acetylated the central glycine-lysine-rich domain of residues 170 to 200, and PCAF also acetylated YY1 at the C-terminal DNA-binding zinc finger domain. Acetylation of the central region was required for the full transcriptional repressor activity of YY1 and targeted YY1 for active deacetylation by HDACs. |
|
| Publications: |
1 |
Organism: |
In Vitro |
| + |
SUZ12/EZH2 | up-regulates activity
binding
|
YY1 |
0.732 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-235574 |
|
|
Mus musculus |
C2C12 Cell, Satellite Cell |
| pmid |
sentence |
| 20887952 |
TNF-activated p38a kinase promotes the interaction between YY1 and PRC2, via threonine 372 phosphorylation of EZH2, the enzy- matic subunit of the complex, leading to the for- mation of repressive chromatin on Pax7 promoter. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
YY1 | down-regulates quantity by repression
transcriptional regulation
|
MYC |
0.545 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-268794 |
|
|
Mus musculus |
NIH-3T3 Cell |
| pmid |
sentence |
| 8266081 |
Inhibition of transcriptional regulator Yin-Yang-1 by association with c-Myc.Yin-Yang-1 (YY1) regulates the transcription of many genes, including the oncogenes c-fos and c-myc. Depending on the context, YY1 acts as a transcriptional repressor, a transcriptional activator, or a transcriptional initiator. In cotransfections, c-Myc inhibits both the repressor and the activator functions of YY1, which suggests that one way c-Myc acts is by modulating the activity of YY1. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| Pathways: | NOTCH Signaling |
| + |
YY1 | down-regulates quantity by repression
transcriptional regulation
|
POSTN |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-255621 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 21839814 |
In this study we demonstrate that the ability of the human POSTN promoter to drive transcription mostly depends on the activity of YingYang-1 (YY1) zinc finger transcription factor. YY1, whose regulatory role in biology includes, besides transcriptional control, also chromatin remodeling, DNA damage repair and tumorigenesis, acts as a strong negative modulator of the POSTN expression. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
YY1 | down-regulates quantity by repression
transcriptional regulation
|
HOXB13 |
0.273 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254233 |
|
|
Homo sapiens |
Prostate Gland Cancer Cell |
| pmid |
sentence |
| 19013255 |
Recruitment of HDAC4 by transcription factor YY1 represses HOXB13 to affect cell growth in AR-negative prostate cancers. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
3.0
YY1
- 
- 