| + |
TPSAB1 | up-regulates activity 
binding
|
F2RL1 |
0.253 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-251744 |
|
|
Rattus norvegicus |
|
| pmid |
sentence |
| 21999702 |
Mast cells contribute to tissue repair in fibrous tissues by stimulating proliferation of fibroblasts through the release of tryptase which activates protease-activated receptor-2 (PAR-2).|Taken together, our data show that tryptase can stimulate myoblast proliferation and this effect is part of a signaling cascade dependent on PAR-2 activation and on the downstream activation of COX-2. |
|
| Publications: |
1 |
Organism: |
Rattus Norvegicus |
| + |
Degranulation | up-regulates quantity by expression 
|
TPSAB1 |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-255348 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 24232182 |
Particularly, damage-activated mast cells almost instantly begin to secrete TNFa, histamine and tryptase and then initiate the de novo synthesis of other cytokines, such as interleukin (IL)6 |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
MITF | up-regulates quantity by expression
transcriptional regulation
|
TPSAB1 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-251725 |
|
|
Homo sapiens |
Mast Cell |
| pmid |
sentence |
| 20513998 |
The transcription of tryptase gene in human mast cells is regulated by mi transcription factor |Using mutant constructs of tryptase promoter, we observed that two E-box (CANNTG) motifs including between -817 to -715 and -421 to -202 are able to involve in the transactivation of tryptase gene by MITF-A. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
3.0
TPSAB1
- 
- 