| + |
Degranulation | up-regulates quantity 
|
TNF |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-255347 |
|
|
Homo sapiens |
Mast Cell |
| pmid |
sentence |
| 24232182 |
Particularly, damage-activated mast cells almost instantly begin to secrete TNFa, histamine and tryptase and then initiate the de novo synthesis of other cytokines, such as interleukin (IL)6 |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
Degranulation | up-regulates quantity
|
IL5 |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-255346 |
|
|
Homo sapiens |
Mast Cell |
| pmid |
sentence |
| 17259966 |
The array of mediators released by human mast cells is enormous and explains how mast cells can be involved in so many different physiological and pathophysiological functions. Of particular relevance [...] cytokines, such as IL-3 -basophil recruitment and activation-, IL-5 -eosinophil recruitment and activation- and IL-13 -induction of IgE synthesis by B cells. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
Degranulation | up-regulates quantity
|
IL6 |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-255349 |
|
|
Homo sapiens |
Mast Cell |
| pmid |
sentence |
| 24232182 |
Particularly, damage-activated mast cells almost instantly begin to secrete TNFa, histamine and tryptase and then initiate the de novo synthesis of other cytokines, such as interleukin (IL)6 |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
SRC_kinase_family | up-regulates
|
Degranulation |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254956 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 16470226 |
So, the association of aggregated FcεRI with the preferentially activated LYN in lipid rafts might be sufficient to shift the equilibrium of FcεRI from a nonphosphorylated state to a phosphorylated state, thereby initiating FcεRI-mediated degranulation |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
Degranulation | up-regulates quantity by expression
transcriptional regulation
|
TPSAB1 |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-255348 |
|
|
Homo sapiens |
Mast Cell |
| pmid |
sentence |
| 24232182 |
Particularly, damage-activated mast cells almost instantly begin to secrete TNFa, histamine and tryptase and then initiate the de novo synthesis of other cytokines, such as interleukin (IL)6 |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
3.0
Degranulation