Relation Results

Summary

Name PTPN14
Full Name Tyrosine-protein phosphatase non-receptor type 14
Synonyms Protein-tyrosine phosphatase pez | PEZ, PTPD2
Primary ID Q15678
Links - -
Type protein
Relations 3
Function Protein tyrosine phosphatase which may play a role in the regulation of lymphangiogenesis, cell-cell adhesion, cell-matrix adhesion, cell migration, c ...
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Type: Score: Layout: SPV 
0.4020.2740.2PTPN14BCAR1STAT3CAV1

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▶Modifications Tables

Relations
Regulator
Mechanism
target
score ℹ
+ PTPN14down-regulates img/direct_inhibition.png dephosphorylation BCAR1 0.402
Identifier Residue Sequence Organism Cell Line
SIGNOR-197923 Tyr128 SKAQQGLyQVPGPSP Homo sapiens Colonic Cancer Cell
pmid sentence
We show that p130 crk-associated substrate (p130cas) is a direct substrate of ptpn14 and that ptpn14 specifically regulates p130cas phosphorylation at tyrosine residue 128 (y128) in colorectal cancer (crc) cells. We engineered crc cells homozygous for a p130cas y128f knock-in mutant and found that these cells exhibit significantly reduced migration and colony formation
Publications: 1 Organism: Homo Sapiens
+ PTPN14down-regulates activity img/direct_inhibition.png dephosphorylation STAT3 0.274
Identifier Residue Sequence Organism Cell Line
SIGNOR-277088 Chlorocebus aethiops
pmid sentence
Moreover, dephosphorylation of STAT3 by PTPN14 might occur in the cytoplasm but not in nucleus.|The tyrosine phosphatase PTPN14 inhibits the activation of STAT3 in PEDV infected Vero cells.
Publications: 1 Organism: Chlorocebus Aethiops
+ PTPN14down-regulates activity img/direct_inhibition.png dephosphorylation CAV1 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-277054 Homo sapiens
pmid sentence
Finally, PTPN14 overexpression in B16F10 cells reduced the ability of CAV1 to induce metastasis in vivo.|Moreover, the CAV1 (Y14F) mutant protein was shown to co-immunoprecipitate with PTPN14 even in the absence of E-cadherin, and overexpression of PTPN14 reduced CAV1 phosphorylation on tyrosine 14, as well as suppressed CAV1 enhanced cell migration, invasion and Rac-1 activation in B16F10, metastatic colon [HT29 (US)] and breast cancer (MDA-MB-231) cell lines.
Publications: 1 Organism: Homo Sapiens
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