| + |
phenformin | down-regulates activity 
chemical inhibition
|
KCNJ8 |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-262030 |
|
|
Homo sapiens |
Pancreatic Beta Cell |
| pmid |
sentence |
| 20188727 |
Phenformin has a direct inhibitory effect on the ATP-sensitive potassium channel |Phenformin but not metformin inhibits a number of variants of K(ATP) including the cloned equivalents of currents present in vascular and non-vascular smooth muscle (Kir6.1/SUR2B and Kir6.2/SUR2B) and pancreatic beta-cells (Kir6.2/SUR1). |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Tissue: |
Smooth Muscle |
| + |
KCNJ8 | form complex 
binding
|
KATP channel |
0.644 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-262054 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 28842488 |
ATP-sensitive K+ (KATP) channels, found throughout the body, are generated as octameric complexes consisting of four pore-forming Kir6.1 or Kir6.2 subunits with four regulatory sulfonylurea receptor (SUR1 or SUR2) subunits. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
KCNJ8 | down-regulates activity
binding
|
NLRP3 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-262034 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 31387986 |
We further show that Kir6.1 physically associates with NLRP3 and thus inhibits the interactions between the NLRP3 inflammasome subunits. Our results reveal a previously unrecognized function of Kir6.1 as a negative regulator of the NLRP3 inflammasome |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
3.0
KCNJ8
- 
- 