4.0
Summary
| Name |  CDC37View Modifications |
| Full Name | Hsp90 co-chaperone Cdc37 |
| Synonyms | Hsp90 chaperone protein kinase-targeting subunit, p50Cdc37 | CDC37A |
| Primary ID | Q16543 |
| Links |  -  -  |
| Type | protein |
| Relations | 4 |
| Function | Co-chaperone that binds to numerous kinases and promotes their interaction with the Hsp90 complex, resulting in stabilization and promotion of their activity (PubMed:8666233). Inhibits HSP90AA1 ATPase activity (PubMed:23569206). |
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Modifications Tables
Relations
| Regulator | Mechanism | target | score ℹ | |
|---|---|---|---|---|
| + | PPP5C | down-regulates activity 
dephosphorylation
|
CDC37 | 0.674 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | CSNK2A1 | up-regulates activity 
phosphorylation
|
CDC37 | 0.396 |
| Publications: | 1 | Organism: | In Vitro | |
| + | CSNK2A2 | up-regulates activity
phosphorylation
|
CDC37 | 0.488 |
| Publications: | 1 | Organism: | In Vitro | |
| + | ULK1 | down-regulates activity
phosphorylation
|
CDC37 | 0.2 |
| Publications: | 1 | Organism: | Homo Sapiens | |