Summary

Name PPP5C
Full Name Serine/threonine-protein phosphatase 5
Synonyms PP5, Protein phosphatase T, PP-T, PPT | PPP5
Primary ID P53041
Links - -
Type protein
Relations 12
Function Serine/threonine-protein phosphatase that dephosphorylates a myriad of proteins involved in different signaling pathways including the kinases CSNK1E, ASK1/MAP3K5, PRKDC and RAF1, the nuclear receptors NR3C1, PPARG, ESR1 and ESR2, SMAD proteins and TAU/MAPT (PubMed:14734805, PubMed:14764652, PubMed:14871926, PubMed:15383005, PubMed:15546861, PubMed:16260606, PubMed:16790549, PubMed:16892053, PubMed:19176521, PubMed:19948726, PubMed:21144835, PubMed:22399290, PubMed:22781750, PubMed:23102700, PubMed:9000529, PubMed:30699359). Implicated in wide ranging cellular processes, including apoptosis, differentiation, DNA damage response, cell survival, regulation of ion channels or circadian rhythms, in response to steroid and thyroid hormones, calcium, fatty acids, TGF-beta as well as oxidative and genotoxic stresses (PubMed:14734805, PubMed:14764652, PubMed:14871926, PubMed:15383005, PubMed:15546861, PubMed:16260606, PubMed:16790549, PubMed:16892053, PubMed:19176521, PubMed:19948726, PubMed:21144835, PubMed:22399290, PubMed:22781750, PubMed:23102700, PubMed:9000529, PubMed:30699359). Participates in the control of DNA damage response mechanisms such as checkpoint activation and DNA damage repair through, for instance, the regulation ATM/ATR-signaling and dephosphorylation of PRKDC and TP53BP1 (PubMed:14871926, PubMed:16260606, PubMed:21144835). Inhibits ASK1/MAP3K5-mediated apoptosis induced by oxidative stress (PubMed:23102700). Plays a positive role in adipogenesis, mainly through the dephosphorylation and activation of PPARG transactivation function (By similarity). Also dephosphorylates and inhibits the anti-adipogenic effect of NR3C1 (By similarity). Regulates the circadian rhythms, through the dephosphorylation and activation of CSNK1E (PubMed:16790549). May modulate TGF-beta signaling pathway by the regulation of SMAD3 phosphorylation and protein expression levels (PubMed:22781750). Dephosphorylates and may play a role in the regulation of TAU/MAPT (PubMed:15546861). Through their dephosphorylation, may play a role in the regulation of ions channels such as KCNH2 (By similarity). Dephosphorylate FNIP1, disrupting interaction with HSP90AA1/Hsp90 (PubMed:30699359).

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▶Modifications Tables

Relations

Regulator Mechanism target score ℹ
+ PPP5Cdown-regulates activity img/direct_inhibition.png dephosphorylation CDC37 0.659
Publications: 1 Organism: Homo Sapiens
+ PPP5Cdown-regulates activity img/direct_inhibition.png dephosphorylation NR3C1 0.521
Publications: 1 Organism: Homo Sapiens
+ PPP5Cdown-regulates activity img/direct_inhibition.png dephosphorylation RAF1 0.438
Publications: 1 Organism: In Vitro
+ PPP5Cdown-regulates activity img/direct_inhibition.png dephosphorylation ABCB1 0.2
Publications: 3 Organism: Homo Sapiens
+ PPP5Cdown-regulates activity img/direct_inhibition.png dephosphorylation CILK1 0.2
Publications: 1 Organism: Homo Sapiens
+ CSNK1Dup-regulates activity img/direct-activation.png phosphorylation PPP5C 0.34
Publications: 1 Organism: Homo Sapiens
+ PPP5Cdown-regulates activity img/direct_inhibition.png dephosphorylation MAP3K5 0.584
Publications: 2 Organism: Homo Sapiens, Mus Musculus
+ PPP2R3Cup-regulates activity img/direct-activation.png binding PPP5C 0.353
Publications: 1 Organism: Homo Sapiens
+ HSP90AA1up-regulates img/direct-activation.png binding PPP5C 0.762
Publications: 1 Organism: Homo Sapiens