| + |
NRF1 | up-regulates quantity by expression 
transcriptional regulation
|
TFB2M |
0.556 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-268997 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 15684387 |
Here, we establish that the expression of human TFB1M and TFB2M promoters is governed by nuclear respiratory factors (NRF-1 and NRF-2), key transcription factors implicated in mitochondrial biogenesis. In addition, we show that NRF recognition sites within both TFB promoters are required for maximal trans activation by the PGC-1 family coactivators, PGC-1alpha and PRC |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-268999 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 15684387 |
Here, we establish that the expression of human TFB1M and TFB2M promoters is governed by nuclear respiratory factors (NRF-1 and NRF-2), key transcription factors implicated in mitochondrial biogenesis. In addition, we show that NRF recognition sites within both TFB promoters are required for maximal trans activation by the PGC-1 family coactivators, PGC-1alpha and PRC |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| + |
NRF1 | up-regulates quantity by expression
transcriptional regulation
|
ENOX1 |
0.265 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-261368 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 23939472 |
We found that NRF-1 positively regulates FAM134C and ENOX1, but negatively regulates C3orf10 in human neuroblastoma IMR-32 cells and primary rat cortical neurons. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
NRF1 | up-regulates quantity by expression
transcriptional regulation
|
SLC46A1 |
0.337 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254884 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 20724482 |
Overexpression of NRF-1 or a constitutively active NRF-1 VP-16 construct resulted in increased reporter activity and PCFT mRNA levels. These novel findings identify NRF-1 as a major inducible transcriptional regulator of PCFT gene expression. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
PPARGC1A | up-regulates activity
|
NRF1 |
0.709 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-253391 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 26971449 |
PGC-1 family transcriptional coactivators enhance the activities of the nuclear respiratory factors NRF1 and NRF2, which induce transactivation of many genes encoding mitochondria-specific proteins involved in respiratory chain, mitochondrial DNA transcription/replication and protein import/assembly |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
NRF1 | up-regulates quantity by expression
transcriptional regulation
|
FMR1 |
0.29 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254881 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 11058604 |
We have also shown that USF1, USF2, and alpha-Pal/Nrf-1 are the major transcription factors that bind the promoter in brain and testis extracts and suggest that elevated levels of these factors account in part for elevated FMR1 expression in these organs. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Tissue: |
Testis, Brain |
| + |
NRF1 | up-regulates quantity by expression
transcriptional regulation
|
RETREG3 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-261367 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 23939472 |
We found that NRF-1 positively regulates FAM134C and ENOX1, but negatively regulates C3orf10 in human neuroblastoma IMR-32 cells and primary rat cortical neurons. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
NRF1 | up-regulates quantity by expression
transcriptional regulation
|
SPAST |
0.338 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254885 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 22574173 |
we demonstrate that SPAST transcription is positively regulated by NRF1 and SOX11. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
NRF1 | up-regulates
|
ENOX1 |
0.265 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-261488 |
|
|
Homo sapiens |
IMR-32 Cell |
| pmid |
sentence |
| 23939472 |
We found that NRF-1 positively regulates FAM134C and ENOX1, but negatively regulates C3orf10 in human neuroblastoma IMR-32 cells and primary rat cortical neurons. In IMR-32 cells, FAM134C positively regulates and C3orf10 negatively regulates neurite outgrowth, but ENOX1 plays no role in neurite outgrowth regulation. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-261451 |
|
|
Homo sapiens |
IMR-32 Cell |
| pmid |
sentence |
| 23939472 |
We found that NRF-1 positively regulates FAM134C and ENOX1, but negatively regulates C3orf10 in human neuroblastoma IMR-32 cells and primary rat cortical neurons. In IMR-32 cells, FAM134C positively regulates and C3orf10 negatively regulates neurite outgrowth, but ENOX1 plays no role in neurite outgrowth regulation. |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| + |
PRKAA1 | up-regulates
|
NRF1 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-130076 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 15509864 |
In muscle, it causes increased dna binding by the transcription factors nrf1 (bergeron et al., 2001) and mef2 (zheng et al., 2001), which may be involved in regulation of mitochondrial genes and glut4, respectively. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
NRF1 | down-regulates quantity by repression 
transcriptional regulation
|
BRK1 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-261369 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 23939472 |
We found that NRF-1 positively regulates FAM134C and ENOX1, but negatively regulates C3orf10 in human neuroblastoma IMR-32 cells and primary rat cortical neurons. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
NRF1 | up-regulates
|
RETREG3 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-261489 |
|
|
Homo sapiens |
IMR-32 Cell |
| pmid |
sentence |
| 23939472 |
We found that NRF-1 positively regulates FAM134C and ENOX1, but negatively regulates C3orf10 in human neuroblastoma IMR-32 cells and primary rat cortical neurons. In IMR-32 cells, FAM134C positively regulates and C3orf10 negatively regulates neurite outgrowth, but ENOX1 plays no role in neurite outgrowth regulation. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
3.0
NRF1
- 
- 