| + |
MUSK | up-regulates activity 
phosphorylation
|
DOK7 |
0.745 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-273845 |
Tyr395 |
CLPGTVEyQVPTSLR |
Mus musculus |
|
| pmid |
sentence |
| 20603078 |
Here, we demonstrate that Dok-7 also functions downstream from MuSK, and we identify the proteins that are recruited to the C-terminal domain of Dok-7. We show that Agrin stimulates phosphorylation of two tyrosine residues in the C-terminal domain of Dok-7, which leads to recruitment of two adapter proteins: Crk and Crk-L. Y396 and Y406 are the major tyrosine phosphorylation sites in Dok-7 expressed in C2 myotubes. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-273845 |
Tyr395 |
CLPGTVEyQVPTSLR |
Mus musculus |
C2C12 Cell |
| pmid |
sentence |
| 20603078 |
Here, we demonstrate that Dok-7 also functions downstream from MuSK, and we identify the proteins that are recruited to the C-terminal domain of Dok-7. We show that Agrin stimulates phosphorylation of two tyrosine residues in the C-terminal domain of Dok-7, which leads to recruitment of two adapter proteins: Crk and Crk-L. Y396 and Y406 are the major tyrosine phosphorylation sites in Dok-7 expressed in C2 myotubes. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-273846 |
Tyr405 |
PTSLRAHyDTPRSLC |
Mus musculus |
|
| pmid |
sentence |
| 20603078 |
Here, we demonstrate that Dok-7 also functions downstream from MuSK, and we identify the proteins that are recruited to the C-terminal domain of Dok-7. We show that Agrin stimulates phosphorylation of two tyrosine residues in the C-terminal domain of Dok-7, which leads to recruitment of two adapter proteins: Crk and Crk-L. Y396 and Y406 are the major tyrosine phosphorylation sites in Dok-7 expressed in C2 myotubes. |
|
| Publications: |
3 |
Organism: |
Mus Musculus |
| + |
DOK7 | up-regulates activity
binding
|
CRK |
0.364 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-273847 |
|
|
Mus musculus |
C2C12 Cell |
| pmid |
sentence |
| 20603078 |
Here, we identify two tyrosine residues in Dok-7 that are phosphorylated by Agrin stimulation, and show that two proteins, Crk and Crk-L, are recruited to these phosphorylation sites in Dok-7. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
DOK7 | up-regulates
binding
|
MUSK |
0.745 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-192264 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 23467009 |
In addition, dok7, a cytoplasmic adaptor protein, is also required for musk activation in vivo. This review focuses on the physical interplay between these proteins and musk for activation and downstream signaling, which culminates in nmj formation. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
DOK7 | up-regulates activity
binding
|
CRKL |
0.349 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-273848 |
|
|
Mus musculus |
C2C12 Cell |
| pmid |
sentence |
| 20603078 |
Here, we identify two tyrosine residues in Dok-7 that are phosphorylated by Agrin stimulation, and show that two proteins, Crk and Crk-L, are recruited to these phosphorylation sites in Dok-7. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
3.0
DOK7
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