| + |
BCR-ABL | up-regulates 
phosphorylation
|
CRKL |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-46893 |
Tyr207 |
IPEPAHAyAQPQTTT |
Homo sapiens |
Leukemia Cell |
| pmid |
sentence |
| 9053848 |
Tyrosine 207 in crkl is the bcr/abl phosphorylation sitephosphorylation of y207 provides a binding site for the crkl sh2 domain and potentially for other sh2-containing proteins. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
CRKL | up-regulates activity
binding
|
PIK3CB |
0.451 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-255821 |
|
|
Homo sapiens |
HEK-293FT Cell |
| pmid |
sentence |
| 28723560 |
Here, we identify CRKL as a member of the class of PI3Kβ-interacting proteins. Silencing CRKL expression in PTEN-null human cancer cells leads to a decrease in p110β-dependent PI3K signaling and cell proliferation.In conclusion, our study identified CRKL as an important regulator of PI3K activity in PTEN-deficient tumor cells through its association with p110β/p85. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
ABL1 | down-regulates 
|
CRKL |
0.705 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-175138 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 21779437 |
Negative regulation of crk by abl is essential for the antitumorigenic effects of ephrinb2,similar pathways may operate for crkl |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
DOK7 | up-regulates activity
binding
|
CRKL |
0.351 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-273848 |
|
|
Mus musculus |
C2C12 Cell |
| pmid |
sentence |
| 20603078 |
Here, we identify two tyrosine residues in Dok-7 that are phosphorylated by Agrin stimulation, and show that two proteins, Crk and Crk-L, are recruited to these phosphorylation sites in Dok-7. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
CRKL | up-regulates
binding
|
MAP4K1 |
0.57 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-63991 |
|
|
Homo sapiens |
T-lymphocyte |
| pmid |
sentence |
| 9891069 |
We found that hpk1 interacted with crk and crkl adaptor proteins in vitro and in vivo and that the proline-rich motifs within hpk1 were involved in the differential interaction of hpk1 with the crk proteins and grb2. Crk and crkl not only activated hpk1 but also synergized with hpk1 in the activation of jnk. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
3.0
CRKL
- 
- 