Relation Results

Summary

Name PLEKHG6
Full Name Pleckstrin homology domain-containing family G member 6
Synonyms PH domain-containing family G member 6, Myosin-interacting guanine nucleotide exchange factor, MyoGEF
Primary ID Q3KR16
Links - -
Type protein
Relations 4
Function Guanine nucleotide exchange factor activating the small GTPase RHOA, which, in turn, induces myosin filament formation. Also activates RHOG. Does not ...
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Type: Score: Layout: SPV 
0.2540.4180.5810.298AURKBPLEKHG6PLK1RHOARAC1

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▶Modifications Tables

Relations
Regulator
Mechanism
target
score ℹ
+ AURKBup-regulates img/direct-activation.png phosphorylation PLEKHG6 0.254
Identifier Residue Sequence Organism Cell Line
SIGNOR-204534 Thr544 SPSTRPStPSLEGSQ Homo sapiens
pmid sentence
In this study we report that aurora b-mediated phosphorylation of myogef at thr-544 creates a docking site for plk1, leading to the localization and activation of myogef at the central spindle.
Publications: 1 Organism: Homo Sapiens
+ PLK1up-regulates img/direct-activation.png phosphorylation PLEKHG6 0.418
Identifier Residue Sequence Organism Cell Line
SIGNOR-179954 Thr574 HLVVTEDtDEDAPLV Homo sapiens HeLa Cell
pmid sentence
We reported previously that a guanine nucleotide exchange factor, myogef, localizes to the central spindle, activates rhoa, and is required for cytokinesis. In this study, we have found that plk1 (polo-like kinase 1) can phosphorylate myogef, thereby recruiting myogef to the central spindle as well as enhancing myogef activity toward rhoa. The in vitro kinase assay shows that plk1 can phosphorylate myogef on threonine 574.
Publications: 1 Organism: Homo Sapiens
+ PLEKHG6up-regulates activity img/direct-activation.png guanine nucleotide exchange factor RHOA 0.581
Identifier Residue Sequence Organism Cell Line
SIGNOR-260567 Homo sapiens HEK-293 Cell
pmid sentence
We therefore developed a screening-compatible live-cell imaging assay, using FRET-based biosensors for the prototype GTPases RHOA, RAC1 and CDC4215,19,20 (Extended Data Fig. 2 and Supplementary Note 1)|We found catalytic activities for 45/75 RhoGEFs and 48/63 RhoGAPs| Our data thus not only reveal extensive promiscuity among regulators, but also that the inactivating RhoGAPs are less selective than the activating RhoGEFs (p-value=0.02)(Supplementary Table 2).
Publications: 1 Organism: Homo Sapiens
+ PLEKHG6up-regulates activity img/direct-activation.png guanine nucleotide exchange factor RAC1 0.298
Identifier Residue Sequence Organism Cell Line
SIGNOR-260568 Homo sapiens HEK-293 Cell
pmid sentence
We therefore developed a screening-compatible live-cell imaging assay, using FRET-based biosensors for the prototype GTPases RHOA, RAC1 and CDC4215,19,20 (Extended Data Fig. 2 and Supplementary Note 1)|We found catalytic activities for 45/75 RhoGEFs and 48/63 RhoGAPs| Our data thus not only reveal extensive promiscuity among regulators, but also that the inactivating RhoGAPs are less selective than the activating RhoGEFs (p-value=0.02)(Supplementary Table 2).
Publications: 1 Organism: Homo Sapiens
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