Summary

Name LARP7
Full Name La-related protein 7
Synonyms La ribonucleoprotein domain family member 7, P-TEFb-interaction protein for 7SK stability, PIP7S |
Primary ID Q4G0J3
Links - -
Type protein
Relations 4
Function RNA-binding protein that specifically binds distinct small nuclear RNA (snRNAs) and regulates their processing and function (PubMed:18249148, PubMed:32017898). Specifically binds the 7SK snRNA (7SK RNA) and acts as a core component of the 7SK ribonucleoprotein (RNP) complex, thereby acting as a negative regulator of transcription elongation by RNA polymerase II (PubMed:18249148, PubMed:18483487). The 7SK RNP complex sequesters the positive transcription elongation factor b (P-TEFb) in a large inactive 7SK RNP complex preventing RNA polymerase II phosphorylation and subsequent transcriptional elongation (PubMed:18249148, PubMed:18483487). The 7SK RNP complex also promotes snRNA gene transcription by RNA polymerase II via interaction with the little elongation complex (LEC) (PubMed:28254838). LARP7 specifically binds to the highly conserved 3'-terminal U-rich stretch of 7SK RNA; on stimulation, remains associated with 7SK RNA, whereas P-TEFb is released from the complex (PubMed:18483487, PubMed:18281698). LARP7 also acts as a regulator of mRNA splicing fidelity by promoting U6 snRNA processing (PubMed:32017898). Specifically binds U6 snRNAs and associates with a subset of box C/D RNP complexes

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Modifications Tables

Relations

Regulator Mechanism target score
+ down-regulates quantity by destabilization img/direct_inhibition.png phosphorylation LARP7 0.2
Publications: 1
+ down-regulates quantity by destabilization img/direct_inhibition.png ubiquitination LARP7 0.2
Publications: 1
+ down-regulates activity img/direct_inhibition.png binding P-TEFb 0.609
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png binding HEXIM1 0.713
Publications: 1 Organism: Homo Sapiens