| + |
LARP7 | down-regulates activity 
binding
|
HEXIM1 |
0.708 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-261183 |
|
|
Homo sapiens |
HeLa Cell |
| pmid |
sentence |
| 30824372 |
To investigate whether LARP7 is part of the known 7SK RNP implicated in the regulation of transcription, co‐immunoprecipitation studies were performed using the nuclear extracts of HeLa cells (Fig 3A, lanes 1–4). Antibodies against LARP7, CDK9 and HEXIM1 efficiently precipitated 7SK RNA, whereas no RNA was found in the control (Fig 3A, lower panel, lanes 1–4). Interestingly, HEXIM1, CDK9, CYCT1 and LARP7 were present in all immunopurifications, as determined by mass spectrometry of silver‐stained gels (Fig 3A; data not shown) and western blotting. In conclusion, these experiments show that LARP7 negatively regulates not only viral but also cellular POLII class genes through the 7SK P‐TEFb system. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
HNRNPU | up-regulates quantity by stabilization 
post transcriptional regulation
|
HEXIM1 |
0.249 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-262283 |
|
|
|
|
| pmid |
sentence |
| 17174306 |
In the present study, we show that hnRNP-U specifically enhances the expression of tumor necrosis factor alpha mRNA by increasing its stability, possibly through binding to the 3' untranslated region. We also show that hnRNP-U enhances the expression of several other genes as well, including GADD45A, HEXIM1, HOXA2, IER3, NHLH2, and ZFY, by binding to and stabilizing these mRNAs. |
|
| Publications: |
1 |
| + |
HEXIM1 | up-regulates activity 
relocalization
|
KDM5B |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-273439 |
|
|
Homo sapiens |
MDA-MB-231 Cell |
| pmid |
sentence |
| 31776402 |
We previously reported that the tumor suppressor HEXIM1 is a mediator of KDM5B recruitment to its target genes, and HEXIM1 is required for the inhibition of nuclear hormone receptor activity by KDM5B. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
NPM1 | down-regulates activity
binding
|
HEXIM1 |
0.395 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-260134 |
|
|
Homo sapiens |
Acute Myeloid Leukemia Cell |
| pmid |
sentence |
| 18371977 |
We identified NPM as a novel HEXIM1-binding protein. NPM functioned as a negative regulator of HEXIM1. cytoplasmic localization of endogenous HEXIM1 is detected in an acute myeloid leukemia (AML) cell line containing the NPMc+ mutation, suggesting the physiological importance of HEXIM1-NPMc+ interaction. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
HEXIM1 | down-regulates activity
binding
|
P-TEFb |
0.743 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-260135 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 18371977 |
Studies show that more than half of P-TEFb in cells is associated with HEXIM1, which results in the inactivation of P-TEFb. The mislocalization of HEXIM1 and the increased P-TEFb-dependent transcription caused by NPMc+ suggests that the misregulated activity of PTEFb may contribute to the tumorigenesis of NPMc+ AML. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
3.0
HEXIM1
- 
- 