Relation Results

Summary

Name GRIPAP1
Full Name GRIP1-associated protein 1
Synonyms GRASP-1 | KIAA1167
Primary ID Q4V328
Links - -
Type protein
Relations 5
Function Regulates the endosomal recycling back to the neuronal plasma membrane, possibly by connecting early and late recycling endosomal domains and promotin ...
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Type: Score: Layout: SPV 
0.4230.5220.3170.316CASP3GRIPAP1GRIP1MAP3K1MAPK8

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Relations
Regulator
Mechanism
target
score ℹ
+ CASP3up-regulates activity img/direct-activation.png cleavage GRIPAP1 0.423
Identifier Residue Sequence Organism Cell Line
SIGNOR-260641 Homo sapiens
pmid sentence
These results suggest that the region of GRASP‐1 downstream of the Caspase‐3‐cleavage site is capable of activating the JNK signaling pathway by enhancing the phosphorylation of JNK. these results suggest that full length GRASP‐1 does not enhance JNK pathway activity, possibly due to the inhibitory effect of the N‐terminal fragment on the C‐terminal fragment. In contrast, Caspase‐3 cleavage of GRASP‐1 releases the C‐terminal fragment, which in turn activates JNK signaling by serving as a scaffold protein.
Publications: 1 Organism: Homo Sapiens
+ GRIP1up-regulates activity img/direct-activation.png binding GRIPAP1 0.522
Identifier Residue Sequence Organism Cell Line
SIGNOR-260638 Rattus norvegicus Brain
pmid sentence
We have identified several GRIP-associated proteins (GRASPs) that bind to distinct PDZ domains within GRIP. GRASP-1 is a neuronal rasGEF associated with GRIP and AMPA receptors in vivo. GRIP1 has seven PDZ domains, which mediate protein–protein interactions, allowing the recruitment of GRASP-1 to a large signal-transducing complex
Publications: 1 Organism: Rattus Norvegicus
+ GRIPAP1up-regulates activity img/direct-activation.png binding MAP3K1 0.317
Identifier Residue Sequence Organism Cell Line
SIGNOR-260640 Homo sapiens HEK-293T Cell, Brain
pmid sentence
To examine whether GRASP‐1 interacts with MEKK1 and JNK1 in neurons, co‐immunoprecipitation experiments were performed with detergent‐solubilized extracts from cultured cortical neurons. Both antiJNK1 and anti‐MEKK1 antibodies immunoprecipitated GRASP‐1 from neuronal lysates. These results suggest that GRASP‐1 interacts with MEKK1 and JNK1 in neurons.
Identifier Residue Sequence Organism Cell Line
SIGNOR-260607 Homo sapiens HEK-293T Cell
pmid sentence
We investigated signal transduction pathways that might lie downstream of GRASP-1 and found that GRASP-1 potently activates JNK pathway signaling, with no effect on ERK signaling. Such JNK pathway activating activity requires binding of GRASP-1 to both JNK and the upstream JNK pathway activator MEKK-1.
Publications: 2 Organism: Homo Sapiens
+ GRIPAP1up-regulates activity img/direct-activation.png binding MAPK8 0.316
Identifier Residue Sequence Organism Cell Line
SIGNOR-260639 Homo sapiens HEK-293T Cell, Brain
pmid sentence
To examine whether GRASP‐1 interacts with MEKK1 and JNK1 in neurons, co‐immunoprecipitation experiments were performed with detergent‐solubilized extracts from cultured cortical neurons. Both antiJNK1 and anti‐MEKK1 antibodies immunoprecipitated GRASP‐1 from neuronal lysates. These results suggest that GRASP‐1 interacts with MEKK1 and JNK1 in neurons. GRASP-1 potently activates JNK pathway signaling, with no effect on ERK signaling. Such JNK pathway activating activity requires binding of GRASP-1 to both JNK and the upstream JNK pathway activator MEKK-1.
Publications: 1 Organism: Homo Sapiens
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