Summary

Name MAP3K1
Full Name Mitogen-activated protein kinase kinase kinase 1
Synonyms MAPK/ERK kinase kinase 1, MEK kinase 1, MEKK 1 | MAPKKK1, MEKK, MEKK1
Primary ID Q13233
Links - -
Type protein
Relations 27
Pathways EGFR, Toll like receptors, SAPK/JNK Signaling, TNF alpha, Macrophage polarization
Function Component of a protein kinase signal transduction cascade (PubMed:9808624). Activates the ERK and JNK kinase pathways by phosphorylation of MAP2K1 and MAP2K4 (PubMed:9808624). May phosphorylate the MAPK8/JNK1 kinase (PubMed:17761173). Activates CHUK and IKBKB, the central protein kinases of the NF-kappa-B pathway (PubMed:9808624).

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Modifications Tables

Relations

Regulator Mechanism target score
+ down-regulates img/direct_inhibition.png phosphorylation FADD 0.24
Publications: 1 Organism: Homo Sapiens
Pathways:TNF alpha
+ up-regulates activity img/direct-activation.png phosphorylation MAP2K1 0.54
Publications: 2 Organism: Mus Musculus
+ up-regulates img/direct-activation.png phosphorylation MAP2K7 0.71
Publications: 2 Organism: Homo Sapiens
Pathways:TNF alpha, Toll like receptors
+ up-regulates activity img/direct-activation.png phosphorylation MAP3K1 0.26
Publications: 1 Organism: Homo Sapiens
Pathways:EGFR, Toll like receptors
+ up-regulates img/direct-activation.png phosphorylation, binding MAP3K1 0.07
Publications: 3 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation STAT3 0.15
Publications: 1 Organism: Homo Sapiens
Pathways:EGFR, Macrophage polarization
+ up-regulates activity img/direct-activation.png phosphorylation MAP3K1 0.50
Publications: 1 Organism: Homo Sapiens
Pathways:Macrophage polarization, SAPK/JNK Signaling, TNF alpha
+ up-regulates img/direct-activation.png phosphorylation MAP2K6 0.54
Publications: 1 Organism: Homo Sapiens
Pathways:SAPK/JNK Signaling, Toll like receptors
+ up-regulates activity img/direct-activation.png phosphorylation MAP2K4 0.89
Publications: 2 Organism: Homo Sapiens
Pathways:EGFR, Macrophage polarization, SAPK/JNK Signaling, TNF alpha
+ up-regulates img/direct-activation.png binding MAP3K1
Publications: 1 Organism: Homo Sapiens
Pathways:SAPK/JNK Signaling
+ up-regulates img/direct-activation.png binding MAP3K1 0.54
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation MAP3K1 0.41
Publications: 1 Organism: Homo Sapiens
Pathways:SAPK/JNK Signaling
+ up-regulates activity img/direct-activation.png phosphorylation MEK1/2
Publications: 1 Organism: Mus Musculus
Pathways:EGFR, Toll like receptors
+ up-regulates img/direct-activation.png phosphorylation MAP3K1 0.63
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/indirect-activation.png unknown MAP3K1 0.38
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation MAP3K1 0.50
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding MAP3K1 0.53
Publications: 2 Organism: Homo Sapiens
Pathways:SAPK/JNK Signaling, TNF alpha
+ up-regulates img/direct-activation.png phosphorylation MAP3K1 0.50
Publications: 1 Organism: Homo Sapiens
Pathways:Macrophage polarization, SAPK/JNK Signaling, TNF alpha
+ up-regulates img/direct-activation.png phosphorylation CRTC1 0.41
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding MAP3K1 0.28
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/indirect_inhibition.png unknown MAP3K1 0.06
Publications: 1 Organism: Homo Sapiens