3.0
Summary
| Name |  PAN2View Modifications |
| Full Name | PAN2-PAN3 deadenylation complex catalytic subunit PAN2 |
| Synonyms | EC 3.1.13.4, Inactive ubiquitin carboxyl-terminal hydrolase 52, PAB1P-dependent poly(A, Poly(A, PAN deadenylation complex subunit 2 | KIAA0710, USP52 |
| Primary ID | Q504Q3 |
| Links |  -  -  |
| Type | protein |
| Relations | 3 |
| Function | Catalytic subunit of the poly(A)-nuclease (PAN) deadenylation complex, one of two cytoplasmic mRNA deadenylases involved in general and miRNA-mediated mRNA turnover. PAN specifically shortens poly(A) tails of RNA and the activity is stimulated by poly(A)-binding protein (PABP). PAN deadenylation is followed by rapid degradation of the shortened mRNA tails by the CCR4-NOT complex. Deadenylated mRNAs are then degraded by two alternative mechanisms, namely exosome-mediated 3'-5' exonucleolytic degradation, or deadenylation-dependent mRNA decaping and subsequent 5'-3' exonucleolytic degradation by XRN1. Also acts as an important regulator of the HIF1A-mediated hypoxic response. Required for HIF1A mRNA stability independent of poly(A) tail length regulation. {ECO:0000255|HAMAP-Rule:MF_03182, ECO:0000269|PubMed:14583602, ECO:0000269|PubMed:16284618, ECO:0000269|PubMed:23398456}. |
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Modifications Tables
Relations
| Regulator | Mechanism | target | score ℹ | |
|---|---|---|---|---|
| + | ATM | up-regulates activity 
phosphorylation
|
PAN2 | 0.2 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | PAN2 | form complex 
binding
|
PAN2-PAN3 deadenylation complex | 0.82 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | PAN2 | up-regulates activity
deubiquitination
|
RBBP8 | 0.2 |
| Publications: | 1 | Organism: | Homo Sapiens | |