3.0
Summary
| Name |  RBBP8View Modifications |
| Full Name | DNA endonuclease RBBP8 |
| Synonyms | CtBP-interacting protein, CtIP, Retinoblastoma-binding protein 8, RBBP-8, Retinoblastoma-interacting protein and myosin-like, RIM, Sporulation in the absence of SPO11 protein 2 homolog, SAE2 | CTIP |
| Primary ID | Q99708 |
| Links |  -  -  |
| Type | protein |
| Relations | 15 |
| Function | Endonuclease that cooperates with the MRE11-RAD50-NBN (MRN) complex in DNA-end resection, the first step of double-strand break (DSB) repair through the homologous recombination (HR) pathway. HR is restricted to S and G2 phases of the cell cycle and preferentially repairs DSBs resulting from replication fork collapse. Key determinant of DSB repair pathway choice, as it commits cells to HR by preventing classical non-homologous end-joining (NHEJ). Functions downstream of the MRN complex and ATM, promotes ATR activation and its recruitment to DSBs in the S/G2 phase facilitating the generation of ssDNA. Component of the BRCA1-RBBP8 complex that regulates CHEK1 activation and controls cell cycle G2/M checkpoints on DNA damage (PubMed:10764811, PubMed:10910365, PubMed:15485915, PubMed:16581787, PubMed:16818604, PubMed:17965729, PubMed:19202191, PubMed:19759395, PubMed:20064462, PubMed:20829486). During immunoglobulin heavy chain class-switch recombination, promotes microhomology-mediated alternative end joining (A-NHEJ) and plays an essential role in chromosomal translocations (By similarity). |
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Modifications Tables
Relations
| Regulator | Mechanism | target | score ℹ | |
|---|---|---|---|---|
| + | CyclinA2/CDK2 | up-regulates activity 
phosphorylation
|
RBBP8 | 0.548 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | ATM | down-regulates 
phosphorylation
|
RBBP8 | 0.823 |
| Publications: | 2 | Organism: | Homo Sapiens | |
| + | PKM | up-regulates activity
phosphorylation
|
RBBP8 | 0.2 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | CDK2 | up-regulates
phosphorylation
|
RBBP8 | 0.603 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | ATR | up-regulates
phosphorylation
|
RBBP8 | 0.6 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | PAN2 | up-regulates activity
deubiquitination
|
RBBP8 | 0.2 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | RBBP8 | down-regulates
binding
|
SPEN | 0.522 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | BRCA1 | up-regulates
ubiquitination
|
RBBP8 | 0.836 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | RBBP8 | up-regulates quantity by expression 
transcriptional regulation
|
ATM | 0.823 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | RBBP8 | up-regulates activity
relocalization
|
BRCC ubiquitin ligase complex | 0.593 |
| Publications: | 1 | |||
| + | Cullin 3-RBX1-Skp1 | down-regulates quantity by destabilization
polyubiquitination
|
RBBP8 | 0.285 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | RBBP8 | form complex 
binding
|
BRCA1-C complex | 0.2 |
| Publications: | 1 | |||
| + | KLHL15 | down-regulates quantity by destabilization
binding
|
RBBP8 | 0.488 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | RBBP8 | up-regulates activity
relocalization
|
BRCA1 | 0.836 |
| Publications: | 1 | |||