Relation Results

Summary

Name H3-2
Full Name Histone HIST2H3PS2
Synonyms H3PS2_HUMAN | HIST2H3PS2
Primary ID Q5TEC6
Links - -
Type protein
Relations 12
Function Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DN ...
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Type: Score: Layout: SPV 
0.20.20.20.20.20.20.2KDM3AH3-2SAGA complexKAT2AKAT2BSIRT7BAZ2BSLBP

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▶Modifications Tables

Relations
Regulator
Mechanism
target
score ℹ
+ KDM3Aup-regulates activity img/direct-activation.png demethylation H3-2 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-276843 Lys10 RTKQTARkSTGGKAP Homo sapiens
pmid sentence
Using a biochemical assay coupled with chromatography, we have purified a JmjC domain-containing protein, JHDM2A, which specifically demethylates mono- and dimethyl-H3K9. 
Publications: 1 Organism: Homo Sapiens
+ SAGA complexdown-regulates activity img/direct_inhibition.png acetylation H3-2 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-269633 Lys10 RTKQTARkSTGGKAP Homo sapiens
pmid sentence
The HAT module within the SAGA and ADA complexes acetylates histone H3, mainly on residues K9 and K14.
Identifier Residue Sequence Organism Cell Line
SIGNOR-269641 Lys15 ARKSTGGkAPRKQLA Homo sapiens
pmid sentence
The HAT module within the SAGA and ADA complexes acetylates histone H3, mainly on residues K9 and K14.
Publications: 2 Organism: Homo Sapiens
+ KAT2Adown-regulates activity img/direct_inhibition.png acetylation H3-2 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-269599 Lys10 RTKQTARkSTGGKAP Homo sapiens
pmid sentence
The HAT module within the SAGA and ADA complexes acetylates histone H3, mainly on residues K9 and K14.
Identifier Residue Sequence Organism Cell Line
SIGNOR-269607 Lys15 ARKSTGGkAPRKQLA Homo sapiens
pmid sentence
The HAT module within the SAGA and ADA complexes acetylates histone H3, mainly on residues K9 and K14.
Publications: 2 Organism: Homo Sapiens
+ KAT2Bdown-regulates activity img/direct_inhibition.png acetylation H3-2 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-269616 Lys10 RTKQTARkSTGGKAP Homo sapiens
pmid sentence
The HAT module within the SAGA and ADA complexes acetylates histone H3, mainly on residues K9 and K14.
Identifier Residue Sequence Organism Cell Line
SIGNOR-269624 Lys15 ARKSTGGkAPRKQLA Homo sapiens
pmid sentence
The HAT module within the SAGA and ADA complexes acetylates histone H3, mainly on residues K9 and K14.
Publications: 2 Organism: Homo Sapiens
+ SIRT7up-regulates activity img/direct-activation.png deacetylation H3-2 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-275871 Lys19 TGGKAPRkQLATKAA
pmid sentence
SIRT7 links H3K18 deacetylation to maintenance of oncogenic transformation.|Genome-wide binding studies reveal that SIRT7 binds to promoters of a specific set of gene targets, where it deacetylates H3K18Ac and promotes transcriptional repression.
Identifier Residue Sequence Organism Cell Line
SIGNOR-275877 Lys37 APATGGVkKPHRYRP
pmid sentence
Besides confirming the previously reported histone H3K18 deacylation activity, our results revealed that SIRT7 has an astonishingly high activity to catalyze deacylation of H3K36 and is also catalytically active to deacylate H3K37.
Identifier Residue Sequence Organism Cell Line
SIGNOR-275883 Lys38 PATGGVKkPHRYRPG
pmid sentence
Besides confirming the previously reported histone H3K18 deacylation activity, our results revealed that SIRT7 has an astonishingly high activity to catalyze deacylation of H3K36 and is also catalytically active to deacylate H3K37.
Publications: 3
+ BAZ2Bdown-regulates activity img/direct_inhibition.png binding H3-2 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-266618 Homo sapiens
pmid sentence
The BAZ2B bromodomain has been shown to bind to acetylated H3K14 (H3K14ac), whose presence at promoter regions is generally associated with gene activation. This suggests a potential role for BAZ2B in transcriptional activation.
Publications: 1 Organism: Homo Sapiens
+ SLBPup-regulates quantity by expression img/direct-activation.png translation regulation H3-2 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-265415 Homo sapiens U2-OS Cell
pmid sentence
Synthesis of mature histone mRNA requires only a single processing reaction: an endonucleolytic cleavage between a conserved stem-loop and a purine-rich downstream element to form the 3' end. The stem-loop binding protein (SLBP) is required for processing, and following processing, histone mRNA is transported to the cytoplasm, where SLBP participates in translation of the histone mRNA|We used radiolabeled probes generated by PCR targeting the open reading frame (ORF) to detect histones H2A, H2B, H3, H4, and H1 and used 7SK snRNA as a loading control (Fig. 2A). The abundance of histone H2A, H2B, H3, and H4 mRNAs is reduced to 37% to 70% of control levels in the SLBP knockdown cells when compared to the C2 control.
Publications: 1 Organism: Homo Sapiens
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