Summary

Name SIRT7
Full Name NAD-dependent protein deacetylase sirtuin-7
Synonyms Regulatory protein SIR2 homolog 7, SIR2-like protein 7 | SIR2L7
Primary ID Q9NRC8
Links - -
Type protein
Relations 34
Function NAD-dependent protein-lysine deacylase that can act both as a deacetylase or deacylase (desuccinylase, depropionylase and deglutarylase), depending on the context (PubMed:22722849, PubMed:26907567, PubMed:30653310, PubMed:31542297). Specifically mediates deacetylation of histone H3 at 'Lys-18' (H3K18Ac) (PubMed:22722849, PubMed:30420520). In contrast to other histone deacetylases, displays strong preference for a specific histone mark, H3K18Ac, directly linked to control of gene expression (PubMed:22722849, PubMed:30653310). H3K18Ac is mainly present around the transcription start site of genes and has been linked to activation of nuclear hormone receptors; SIRT7 thereby acts as a transcription repressor (PubMed:22722849). Moreover, H3K18 hypoacetylation has been reported as a marker of malignancy in various cancers and seems to maintain the transformed phenotype of cancer cells (PubMed:22722849). Also able to mediate deacetylation of histone H3 at 'Lys-36' (H3K36Ac) in the context of nucleosomes (PubMed:30653310). Also mediates deacetylation of non-histone proteins, such as ATM, CDK9, DDX21, DDB1, FBL, FKBP5/FKBP51, GABPB1, RAN, RRP9/U3-55K and POLR1E/PAF53 (PubMed:24207024, PubMed:26867678, PubMed:28147277, PubMed:28886238, PubMed:28426094, PubMed:30540930, PubMed:31075303, PubMed:30944854, PubMed:28790157). Enriched in nucleolus where it stimulates transcription activity of the RNA polymerase I complex (PubMed:16618798, PubMed:19174463, PubMed:24207024). Acts by mediating the deacetylation of the RNA polymerase I subunit POLR1E/PAF53, thereby promoting the association of RNA polymerase I with the rDNA promoter region and coding region (PubMed:16618798, PubMed:19174463, PubMed:24207024). In response to metabolic stress, SIRT7 is released from nucleoli leading to hyperacetylation of POLR1E/PAF53 and decreased RNA polymerase I transcription (PubMed:24207024). Required to restore the transcription of ribosomal RNA (rRNA) at the exit from mitosis (PubMed:19174463). Promotes pre-ribosomal RNA (pre-rRNA) cleavage at the 5'-terminal processing site by mediating deacetylation of RRP9/U3-55K, a core subunit of the U3 snoRNP complex (PubMed:26867678). Mediates 'Lys-37' deacetylation of Ran, thereby regulating the nuclear export of NF-kappa-B subunit RELA/p65 (PubMed:31075303). Acts as a regulator of DNA damage repair by mediating deacetylation of ATM during the late stages of DNA damage response, promoting ATM dephosphorylation and deactivation (PubMed:30944854). Suppresses the activity of the DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complexes by mediating deacetylation of DDB1, which prevents the interaction between DDB1 and CUL4 (CUL4A or CUL4B) (PubMed:28886238). Activates RNA polymerase II transcription by mediating deacetylation of CDK9, thereby promoting 'Ser-2' phosphorylation of the C-terminal domain (CTD) of RNA polymerase II (PubMed:28426094). Deacetylates FBL, promoting histone-glutamine methyltransferase activity of FBL (PubMed:30540930). Acts as a regulator of mitochondrial function by catalyzing deacetylation of GABPB1 (By similarity). Regulates Akt/AKT1 activity by mediating deacetylation of FKBP5/FKBP51 (PubMed:28147277). Required to prevent R-loop-associated DNA damage and transcription-associated genomic instability by mediating deacetylation and subsequent activation of DDX21, thereby overcoming R-loop-mediated stalling of RNA polymerases (PubMed:28790157). In addition to protein deacetylase activity, also acts as protein-lysine deacylase (PubMed:27436229, PubMed:27997115, PubMed:31542297). Acts as a protein depropionylase by mediating depropionylation of Osterix (SP7), thereby regulating bone formation by osteoblasts (By similarity). Acts as a histone deglutarylase by mediating deglutarylation of histone H4 on 'Lys-91' (H4K91glu); a mark that destabilizes nucleosomes by promoting dissociation of the H2A-H2B dimers from nucleosomes (PubMed:31542297). Acts as a histone desuccinylase

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▶Modifications Tables

Relations

Regulator Mechanism target score ℹ
+ PRMT6down-regulates activity img/direct_inhibition.png methylation SIRT7 0.262
Publications: 1
+ SIRT7up-regulates activity img/direct-activation.png deacetylation FBL 0.274
Publications: 4
+ SIRT7up-regulates activity img/direct-activation.png deacetylation DDX21 0.262
Publications: 3
+ SIRT7up-regulates activity img/direct-activation.png deacetylation H3C1 0.2
Publications: 3
+ SIRT7up-regulates activity img/direct-activation.png deacetylation H3-3A 0.2
Publications: 3
+ SIRT7up-regulates activity img/direct-activation.png deacetylation H3C15 0.2
Publications: 3
+ SIRT7up-regulates activity img/direct-activation.png deacetylation H3-4 0.2
Publications: 3
+ SIRT7up-regulates activity img/direct-activation.png deacetylation H3-2 0.2
Publications: 3
+ SIRT7up-regulates activity img/direct-activation.png deacetylation H3-5 0.2
Publications: 3
+ SIRT7down-regulates activity img/direct_inhibition.png deacetylation ATM 0.368
Publications: 1
+ SIRT7down-regulates activity img/direct_inhibition.png deacetylation RAN 0.2
Publications: 1
+ PRKAA1down-regulates quantity by destabilization img/direct_inhibition.png phosphorylation SIRT7 0.2
Publications: 1
+ AMPKdown-regulates quantity by destabilization img/direct_inhibition.png phosphorylation SIRT7 0.2
Publications: 1
+ SIRT7down-regulates img/direct_inhibition.png deacetylation TP53 0.514
Publications: 1 Organism: Homo Sapiens
+ SIRT7down-regulates activity img/direct_inhibition.png deacetylation DDB1 0.364
Publications: 1
+ SIRT7up-regulates activity img/direct-activation.png deacetylation SAR1A 0.2
Publications: 1 Organism: Homo Sapiens
+ PSME3down-regulates quantity by destabilization img/direct_inhibition.png binding SIRT7 0.2
Publications: 1