Summary

Name KDM3A
Full Name Lysine-specific demethylase 3A
Synonyms JmjC domain-containing histone demethylation protein 2A, Jumonji domain-containing protein 1A, [histone H3]-dimethyl-L-lysine(9) demethylase 3A | JHDM2A, JMJD1, JMJD1A, KIAA0742, TSGA
Primary ID Q9Y4C1
Links - -
Type protein
Relations 10
Function Histone demethylase that specifically demethylates 'Lys-9' of histone H3, thereby playing a central role in histone code. Preferentially demethylates mono- and dimethylated H3 'Lys-9' residue, with a preference for dimethylated residue, while it has weak or no activity on trimethylated H3 'Lys-9'. Demethylation of Lys residue generates formaldehyde and succinate. Involved in hormone-dependent transcriptional activation, by participating in recruitment to androgen-receptor target genes, resulting in H3 'Lys-9' demethylation and transcriptional activation. Involved in spermatogenesis by regulating expression of target genes such as PRM1 and TNP1 which are required for packaging and condensation of sperm chromatin. Involved in obesity resistance through regulation of metabolic genes such as PPARA and UCP1.

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▶Modifications Tables

Relations

Regulator Mechanism target score ℹ
+ KDM3Aup-regulates activity img/direct-activation.png demethylation H3-2 0.2
Publications: 1 Organism: Homo Sapiens
+ KDM3Aup-regulates activity img/direct-activation.png demethylation H3-4 0.2
Publications: 1 Organism: Homo Sapiens
+ KDM3Aup-regulates activity img/direct-activation.png demethylation H3-3A 0.2
Publications: 1 Organism: Homo Sapiens
+ KDM3Aup-regulates activity img/direct-activation.png demethylation H3C15 0.2
Publications: 1 Organism: Homo Sapiens
+ KDM3Aup-regulates activity img/direct-activation.png demethylation H3-5 0.2
Publications: 1 Organism: Homo Sapiens
+ TNK2down-regulates activity img/direct_inhibition.png phosphorylation KDM3A 0.377
Publications: 1 Organism: Homo Sapiens
+ HIF1Aup-regulates quantity by expression img/direct-activation.png transcriptional regulation KDM3A 0.425
Publications: 1 Organism: Homo Sapiens
+ EPAS1up-regulates quantity by expression img/direct-activation.png transcriptional regulation KDM3A 0.268
Publications: 1 Organism: Homo Sapiens
+ NANOGP8down-regulates quantity by repression img/indirect_inhibition.png transcriptional regulation KDM3A 0.2
Publications: 1 Organism: Bluetongue Virus (serotype 10 / American Isolate)
+ 2-oxoglutarate(2-)up-regulates activity img/direct-activation.png chemical activation KDM3A 0.8
Publications: 1