| + |
E4F1 | up-regulates activity 
ubiquitination
|
TP53 |
0.591 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-271394 |
Lys319 |
TSSSPQPkKKPLDGE |
Homo sapiens |
U2-OS Cell |
| pmid |
sentence |
| 17110336 |
E4F1 Has an Intrinsic Ubiquitin E3 Ligase Activity that Drives K48-type Ubiquitylation of p53. These data demonstrate that E4F1 stimulates the ubiquitylation of p53 on the lysine cluster K319–K321, i.e., at sites distinct from those targeted by Hdm2. p53 forms Ubiquitylated by E4F1 Are Localized on Chromatin. In striking contrast with Ub-p53 forms stimulated by Hdm2, which are mainly cytosoluble and targeted to the proteasome, we found that E4F1-stimulated Ub-p53 forms are tightly associated with chromatin, suggesting that they could be involved in transcription. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-271395 |
Lys321 |
SSPQPKKkPLDGEYF |
Homo sapiens |
U2-OS Cell |
| pmid |
sentence |
| 17110336 |
E4F1 Has an Intrinsic Ubiquitin E3 Ligase Activity that Drives K48-type Ubiquitylation of p53. These data demonstrate that E4F1 stimulates the ubiquitylation of p53 on the lysine cluster K319–K321, i.e., at sites distinct from those targeted by Hdm2. p53 forms Ubiquitylated by E4F1 Are Localized on Chromatin. In striking contrast with Ub-p53 forms stimulated by Hdm2, which are mainly cytosoluble and targeted to the proteasome, we found that E4F1-stimulated Ub-p53 forms are tightly associated with chromatin, suggesting that they could be involved in transcription. |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| + |
HMGA2 | down-regulates 
binding
|
E4F1 |
0.378 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-119537 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 14645522 |
Here we show that hmga2 associates with the e1a-regulated transcriptional repressor p120(e4f), interfering with p120(e4f) binding to the cyclin a promoter |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
3.0
E4F1
- 
- 