Relation Results

Summary

Name	USP17L2
Full Name	Ubiquitin carboxyl-terminal hydrolase 17
Synonyms	USP17, EC 3.4.19.12, Deubiquitinating enzyme 17-like protein 2, Deubiquitinating protein 3, DUB-3, Ubiquitin carboxyl-terminal hydrolase 17-like protein 2, Ubiquitin thioesterase 17-like protein 2, Ubiquitin-specific-processing protease 17-like protein 2 \| DUB3, USP17, USP17H, USP17I, USP17J, USP17K, USP17L, USP17M
Primary ID	Q6R6M4
Links	- -
Type	protein
Relations	2
Function	Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. Regulates cell proliferation by deubiquitinating and inhibiting RCE1 thereby controlling the small GTPases NRAS and HRAS localization and activation. In parallel, mediates deubiquitination of CDC25A, preventing CDC25A degradation by the proteasome during the G1/S and G2/M phases promoting cell-cycle progression. Also regulates cell proliferation and apoptosis through deubiquitination of SUDS3 a regulator of histone deacetylation. Through activation of the Rho family GTPases RAC1A, CDC42 and RHOA, regulates cell migration. Through the cleavage of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains of the cytoplasmic innate immune receptors RIGI and IFIH1 stimulates the cellular response to viral infection. {ECO:0000269\|PubMed:14699124, ECO:0000269\|PubMed:17109758, ECO:0000269\|PubMed:19188362, ECO:0000269\|PubMed:20147298, ECO:0000269\|PubMed:20228808, ECO:0000269\|PubMed:20368735, ECO:0000269\|PubMed:20388806, ECO:0000269\|PubMed:21239494, ECO:0000269\|PubMed:21448158}.