3.0
Summary
| Name |  BHLHE40View Modifications |
| Full Name | Class E basic helix-loop-helix protein 40 |
| Synonyms | bHLHe40, Class B basic helix-loop-helix protein 2, bHLHb2, Differentially expressed in chondrocytes protein 1, DEC1, Enhancer-of-split and hairy-related protein 2, SHARP-2, Stimulated by retinoic acid gene 13 protein | BHLHB2, DEC1, SHARP2, STRA13 |
| Primary ID | O14503 |
| Links |  -  -  |
| Type | protein |
| Relations | 11 |
| Function | Transcriptional repressor involved in the regulation of the circadian rhythm by negatively regulating the activity of the clock genes and clock-controlled genes (PubMed:12397359, PubMed:18411297). Acts as the negative limb of a novel autoregulatory feedback loop (DEC loop) which differs from the one formed by the PER and CRY transcriptional repressors (PER/CRY loop) (PubMed:14672706). Both these loops are interlocked as it represses the expression of PER1/2 and in turn is repressed by PER1/2 and CRY1/2 (PubMed:15193144). Represses the activity of the circadian transcriptional activator |
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Modifications Tables
Relations
| Regulator | Mechanism | target | score ℹ | |
|---|---|---|---|---|
| + | CSNK1A1 | down-regulates quantity by destabilization 
phosphorylation
|
BHLHE40 | 0.2 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | UBE2I | down-regulates quantity by destabilization
polyubiquitination
|
BHLHE40 | 0.331 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | BHLHE41 | down-regulates quantity by repression 
transcriptional regulation
|
BHLHE40 | 0.516 |
| Publications: | 1 | Organism: | Mus Musculus | |
| + | BHLHE40 | down-regulates quantity by repression
transcriptional regulation
|
BHLHE41 | 0.516 |
| Publications: | 1 | Organism: | Mus Musculus | |
| + | NR1H2 | up-regulates quantity by expression 
transcriptional regulation
|
BHLHE40 | 0.2 |
| Publications: | 1 | Organism: | Mus Musculus | |
| + | USP17L2 | up-regulates quantity by stabilization 
deubiquitination
|
BHLHE40 | 0.2 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | NR1H3 | up-regulates quantity by expression
transcriptional regulation
|
BHLHE40 | 0.271 |
| Publications: | 1 | Organism: | Mus Musculus | |
| + | CLOCK/BMAL1 | up-regulates quantity by expression
transcriptional regulation
|
BHLHE40 | 0.652 |
| Publications: | 1 | Organism: | Mus Musculus | |
| + | SCF-betaTRCP | down-regulates quantity by destabilization
ubiquitination
|
BHLHE40 | 0.351 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | BHLHE40 | down-regulates quantity by repression
transcriptional regulation
|
PER2 | 0.486 |
| Publications: | 1 | Organism: | Mus Musculus | |
| + | BHLHE40 | down-regulates quantity by repression
transcriptional regulation
|
BHLHE40 | 0.2 |
| Publications: | 1 | Organism: | Mus Musculus | |