3.0
Summary
| Name |  LGMNView Modifications |
| Full Name | Legumain |
| Synonyms | EC 3.4.22.34, Asparaginyl endopeptidase, Protease, cysteine 1 | PRSC1 |
| Primary ID | Q99538 |
| Links |  -  -  |
| Type | protein |
| Relations | 4 |
| Function | Has a strict specificity for hydrolysis of asparaginyl bonds. Can also cleave aspartyl bonds slowly, especially under acidic conditions. Required for normal lysosomal protein degradation in renal proximal tubules. Required for normal degradation of internalized EGFR. Plays a role in the regulation of cell proliferation via its role in EGFR degradation (By similarity). May be involved in the processing of proteins for MHC class II antigen presentation in the lysosomal/endosomal system. {ECO:0000250, ECO:0000269|PubMed:23776206}. |
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Modifications Tables
Relations
| Regulator | Mechanism | target | score ℹ | |
|---|---|---|---|---|
| + | SRPK2 | up-regulates activity 
phosphorylation
|
LGMN | 0.2 |
| Publications: | 1 | Organism: | Rattus Norvegicus | |
| + | HSP90AA1 | up-regulates quantity by stabilization
binding
|
LGMN | 0.2 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | USP17L2 | down-regulates quantity by destabilization 
deubiquitination
|
LGMN | 0.314 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | TRAF6 | up-regulates quantity by stabilization
polyubiquitination
|
LGMN | 0.312 |
| Publications: | 1 | Organism: | Homo Sapiens | |