Summary

Name CRTC1
Full Name CREB-regulated transcription coactivator 1
Synonyms Mucoepidermoid carcinoma translocated protein 1, Transducer of regulated cAMP response element-binding protein 1, TORC-1, Transducer of CREB protein 1 | KIAA0616, MECT1, TORC1, WAMTP1
Primary ID Q6UUV9
Links - -
Type protein
Relations 5
Function Transcriptional coactivator for CREB1 which activates transcription through both consensus and variant cAMP response element (CRE) sites. Acts as a coactivator, in the SIK/TORC signaling pathway, being active when dephosphorylated and acts independently of CREB1 'Ser-133' phosphorylation. Enhances the interaction of CREB1 with TAF4. Regulates the expression of specific CREB-activated genes such as the steroidogenic gene, StAR. Potent coactivator of PGC1alpha and inducer of mitochondrial biogenesis in muscle cells. In the hippocampus, involved in late-phase long-term potentiation (L-LTP) maintenance at the Schaffer collateral-CA1 synapses. May be required for dendritic growth of developing cortical neurons (By similarity). In concert with SIK1, regulates the light-induced entrainment of the circadian clock. In response to light stimulus, coactivates the CREB-mediated transcription of PER1 which plays an important role in the photic entrainment of the circadian clock.

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▶Modifications Tables

Relations

Regulator Mechanism target score ℹ
+ SIK1down-regulates img/direct_inhibition.png phosphorylation CRTC1 0.496
Publications: 1 Organism: Homo Sapiens
+ PRKAA1down-regulates img/direct_inhibition.png phosphorylation CRTC1 0.285
Publications: 1 Organism: Homo Sapiens
+ AMPKdown-regulates img/direct_inhibition.png phosphorylation CRTC1 0.285
Publications: 1 Organism: Homo Sapiens
+ SIRT1up-regulates img/direct-activation.png deacetylation CRTC1 0.282
Publications: 1 Organism: Homo Sapiens
Tissue: Brain
+ MAP3K1up-regulates img/direct-activation.png phosphorylation CRTC1 0.32
Publications: 1 Organism: Homo Sapiens