Summary

Name MPRIP
Full Name Myosin phosphatase Rho-interacting protein
Synonyms M-RIP, Rho-interacting protein 3, RIP3, p116Rip | KIAA0864, MRIP, RHOIP3
Primary ID Q6WCQ1
Links - -
Type protein
Relations 1
Function Targets myosin phosphatase to the actin cytoskeleton. Required for the regulation of the actin cytoskeleton by RhoA and ROCK1. Depletion leads to an increased number of stress fibers in smooth muscle cells through stabilization of actin fibers by phosphorylated myosin. Overexpression of MRIP as well as its F-actin-binding region leads to disassembly of stress fibers in neuronal cells.

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Relations

Regulator Mechanism target score
+ down-regulates img/direct_inhibition.png phosphorylation MPRIP 0.304
Publications: 1 Organism: Homo Sapiens