Relation Results

Summary

Name STXBP4
Full Name Syntaxin-binding protein 4
Synonyms Syntaxin 4-interacting protein, STX4-interacting protein, Synip |
Primary ID Q6ZWJ1
Links - -
Type protein
Relations 3
Function Plays a role in the translocation of transport vesicles from the cytoplasm to the plasma membrane. Inhibits the translocation of SLC2A4 from intracell ...
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Type: Score: Layout: SPV 
0.430.7920.2AKT2STXBP4STX4YAP1

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▶Modifications Tables

Relations
Regulator
Mechanism
target
score ℹ
+ AKT2down-regulates activity img/direct_inhibition.png phosphorylation STXBP4 0.43
Identifier Residue Sequence Organism Cell Line
SIGNOR-262635 Ser99 GAKLRLEsAWEIAFI Cricetulus griseus CHO Cell
pmid sentence
Akt2 phosphorylates Synip to regulate docking and fusion of GLUT4-containing vesicles. These data demonstrate that insulin activation of Akt2 specifically regulates the docking/fusion step of GLUT4-containing vesicles at the plasma membrane through the regulation of Synip phosphorylation and Synip-Syntaxin4 interaction.Thus, our data demonstrate that insulin-stimulated Akt2-dependent phosphorylation of Synip on serine residue 99 results in reduced binding interactions between Synip and Syntaxin4.
Publications: 1 Organism: Cricetulus Griseus
+ STXBP4up-regulates activity img/direct-activation.png binding STX4 0.792
Identifier Residue Sequence Organism Cell Line
SIGNOR-262634 Cricetulus griseus CHO Cell
pmid sentence
Akt2 phosphorylates Synip to regulate docking and fusion of GLUT4-containing vesicles. These data demonstrate that insulin activation of Akt2 specifically regulates the docking/fusion step of GLUT4-containing vesicles at the plasma membrane through the regulation of Synip phosphorylation and Synip-Syntaxin4 interaction.Thus, our data demonstrate that insulin-stimulated Akt2-dependent phosphorylation of Synip on serine residue 99 results in reduced binding interactions between Synip and Syntaxin4.
Publications: 1 Organism: Cricetulus Griseus
+ STXBP4down-regulates activity img/direct_inhibition.png binding YAP1 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-260013 in vitro
pmid sentence
WW domain‐containing protein STXBP4 inhibits YAP activity via LATS1‐mediated phosphorylation.
Publications: 1 Organism: In Vitro
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