Relation Results

Name	ASXL2
Full Name	Putative Polycomb group protein ASXL2
Synonyms	Additional sex combs-like protein 2 \| ASXH2, KIAA1685
Primary ID	Q76L83
Links	- -
Type	protein
Relations	2
Pathways	Acute Myeloid Leukemia, IDH-TET in AML
Function	Putative Polycomb group (PcG) protein. PcG proteins act by forming multiprotein complexes, which are required to maintain the transcriptionally repressive state of homeotic genes throughout development. PcG proteins are not required to initiate repression, but to maintain it during later stages of development. They probably act via methylation of histones, rendering chromatin heritably changed in its expressibility (By similarity). Involved in transcriptional regulation mediated by ligand-bound nuclear hormone receptors, such as peroxisome proliferator-activated receptor gamma (PPARG). Acts as coactivator for PPARG and enhances its adipocyte differentiation-inducing activity; the function seems to involve differential recruitment of acetylated and methylated histone H3.