Summary

Name RHOU
Full Name Rho-related GTP-binding protein RhoU
Synonyms CDC42-like GTPase 1, GTP-binding protein-like 1, Rho GTPase-like protein ARHU, Ryu GTPase, Wnt-1 responsive Cdc42 homolog 1, WRCH-1 | ARHU, CDC42L1, G28K, WRCH1
Primary ID Q7L0Q8
Links - -
Type protein
Relations 1
Function Acts upstream of PAK1 to regulate the actin cytoskeleton, adhesion turnover and increase cell migration. Stimulates quiescent cells to reenter the cell cycle. Has no detectable GTPase activity but its high intrinsic guanine nucleotide exchange activity suggests it is constitutively GTP-bound. Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the control of cell shape.

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Relations

Regulator Mechanism target score
+ down-regulates activity img/direct_inhibition.png phosphorylation RHOU 0.539
Publications: 1 Organism: Homo Sapiens