| + |
has-mir-126-3p | down-regulates quantity by repression 
post transcriptional regulation
|
CXCR4 |
0.4 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-277930 |
|
|
Homo sapiens |
HCT-116 Cell |
| pmid |
sentence |
| 27517626 |
Our findings suggested that miR-126 acts as a tumor suppressor by inactivating the RhoA signaling pathway via CXCR4 in colon cancer. And miR-126 may serve as a prognostic marker for monitoring and treating colon cancer. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
has-mir-126-3p | down-regulates quantity by repression
post transcriptional regulation
|
LRP6 |
0.4 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-279928 |
|
|
Mus musculus |
HL-1 Cell |
| pmid |
sentence |
| 23811937 |
To understand the role of LRP6 in miR-126-mediated Wnt/β-catenin signaling pathway, we examined the downstream gene expression after CVB3 infection. We confirmed that miR-126 mimetic suppressed LRP6 expression |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-278836 |
|
|
Homo sapiens |
Hep-G2 Cell |
| pmid |
sentence |
| 25240815 |
These results provided strong evidence that LRP6 is a target of miR-126-3p in HCC and mediates the metastasis function of miR-126-3p in HCC. | MiR-126-3p inhibits HCC metastasis by directly targeting LRP6. |
|
| Publications: |
2 |
Organism: |
Mus Musculus, Homo Sapiens |
| + |
has-mir-126-3p | down-regulates quantity by repression
post transcriptional regulation
|
RHOU |
0.4 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-279929 |
|
|
Mus musculus |
HL-1 Cell |
| pmid |
sentence |
| 23811937 |
To understand the role of and RHOU in miR-126-mediated Wnt/β-catenin signaling pathway, we examined the downstream gene expression after CVB3 infection. We first confirmed that miR-126 mimetic suppressed RHOU expression, while miR-126 inhibitor increased WRCH1 expression. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
has-mir-126-3p | down-regulates quantity by repression
post transcriptional regulation
|
VCAM1 |
0.4 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-279930 |
|
|
Homo sapiens |
HEK-293A Cell |
| pmid |
sentence |
| 26968021 |
The results suggest that miR-126a-3p could directly bind and inhibit the expression of VCAM-1. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
has-mir-126-3p | down-regulates quantity by repression
post transcriptional regulation
|
SPRED1 |
0.4 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-279931 |
|
|
Homo sapiens |
HEK-293A Cell |
| pmid |
sentence |
| 26968021 |
The results suggest that miR-126a-3p could directly bind and inhibit the expression of SPRED1. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
has-mir-126-3p | down-regulates quantity by repression
post transcriptional regulation
|
PIK3R2 |
0.4 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-278837 |
|
|
Homo sapiens |
Hep-G2 Cell |
| pmid |
sentence |
| 25240815 |
We demonstrated that miR-126-3p was shown to directly bind to the 3′UTR of PIK3R2 by both up-regulation and inhibition of miR-126-3p in Hep-G2 and BEL-7402 cells.| These data suggests that miR-126-3p suppresses angiogenesis in HCC through PIK3R2/P-AKT pathway. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
has-mir-126-3p | down-regulates 
|
Metastasis |
0.4 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-280442 |
|
|
Homo sapiens |
Hep-G2 Cell |
| pmid |
sentence |
| 25240815 |
Both gain- of function and loss- of function assays indicate that miR-126-3p suppresses metastasis and angiogenesis in HCC cells. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
has-mir-126-3p | down-regulates
|
Angiogenesis |
0.4 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-280443 |
|
|
Homo sapiens |
Hep-G2 Cell |
| pmid |
sentence |
| 25240815 |
Both gain- of function and loss- of function assays indicate that miR-126-3p suppresses metastasis and angiogenesis in HCC cells. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
4.0
has-mir-126-3p
