+ |
ULK1 | up-regulates activity
phosphorylation
|
ATG9A |
0.6 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-266369 |
Ser14 |
EYQRLEAsYSDSPPG |
Homo sapiens |
|
pmid |
sentence |
27934868 |
Src phosphorylates mATG9 at Tyr8 to maintain its endocytic and constitutive trafficking in unstressed conditions. In response to starvation, phosphorylation of mATG9 at Tyr8 by Src and at Ser14 by ULK1 functionally cooperate to promote interactions between mATG9 and the AP1/2 complex, leading to redistribution of mATG9 from the plasma membrane and juxta-nuclear region to the peripheral pool for autophagy initiation. |
|
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-266366 |
Ser761 |
QSIPRSAsYPCAAPR |
Homo sapiens |
|
pmid |
sentence |
25266655 |
Our data suggest that the localization of mammalian Atg9A to autophagosomes requires phosphorylation on the C terminus of Atg9A at S761, which creates a 14-3-3ζ docking site. Under basal conditions, this phosphorylation is maintained at a low level and is dependent on both ULK1 and AMPK. |
|
Publications: |
2 |
Organism: |
Homo Sapiens |
+ |
AMPK | up-regulates activity
phosphorylation
|
ATG9A |
0.251 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-266365 |
Ser761 |
QSIPRSAsYPCAAPR |
Homo sapiens |
|
pmid |
sentence |
25266655 |
Our data suggest that the localization of mammalian Atg9A to autophagosomes requires phosphorylation on the C terminus of Atg9A at S761, which creates a 14-3-3ζ docking site. Under basal conditions, this phosphorylation is maintained at a low level and is dependent on both ULK1 and AMPK. |
|
Publications: |
1 |
Organism: |
Homo Sapiens |
+ |
SRC | up-regulates activity
phosphorylation
|
ATG9A |
0.35 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-266367 |
Tyr8 |
MAQFDTEyQRLEASY |
Homo sapiens |
|
pmid |
sentence |
27934868 |
Src phosphorylates mATG9 at Tyr8 to maintain its endocytic and constitutive trafficking in unstressed conditions. In response to starvation, phosphorylation of mATG9 at Tyr8 by Src and at Ser14 by ULK1 functionally cooperate to promote interactions between mATG9 and the AP1/2 complex, leading to redistribution of mATG9 from the plasma membrane and juxta-nuclear region to the peripheral pool for autophagy initiation. |
|
Publications: |
1 |
Organism: |
Homo Sapiens |
+ |
ATG9A | up-regulates activity
binding
|
YWHAE |
0.2 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-266368 |
|
|
Homo sapiens |
|
pmid |
sentence |
25266655 |
Our data suggest that the localization of mammalian Atg9A to autophagosomes requires phosphorylation on the C terminus of Atg9A at S761, which creates a 14-3-3ζ docking site. Under basal conditions, this phosphorylation is maintained at a low level and is dependent on both ULK1 and AMPK. |
|
Publications: |
1 |
Organism: |
Homo Sapiens |