3.0
Summary
| Name |  SPRED1View Modifications |
| Full Name | Sprouty-related, EVH1 domain-containing protein 1 |
| Synonyms | Spred-1, hSpred1 | |
| Primary ID | Q7Z699 |
| Links |  -  -  |
| Type | protein |
| Relations | 3 |
| Function | Tyrosine kinase substrate that inhibits growth-factor-mediated activation of MAP kinase (By similarity). Negatively regulates hematopoiesis of bone marrow (By similarity). Inhibits fibroblast growth factor (FGF)-induced retinal lens fiber differentiation, probably by inhibiting FGF-mediated phosphorylation of ERK1/2 (By similarity). Attenuates actin stress fiber formation via inhibition of TESK1-mediated phosphorylation of cofilin (PubMed:18216281). Inhibits TGFB-induced epithelial-to-mesenchymal transition in lens epithelial cells (By similarity). |
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Modifications Tables
Relations
| Regulator | Mechanism | target | score ℹ | |
|---|---|---|---|---|
| + | EGFR | down-regulates activity 
phosphorylation
|
SPRED1 | 0.275 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | SPRED1 | up-regulates quantity 
binding
|
NF1 | 0.627 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | hsa-mir-126-5p | down-regulates quantity by repression
post transcriptional regulation
|
SPRED1 | 0.4 |
| Publications: | 1 | Organism: | Homo Sapiens | |