| + |
FBXO33 | down-regulates quantity by destabilization 
polyubiquitination
|
EIF3F |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-271768 |
|
|
Mus musculus |
C2C12 Cell |
| pmid |
sentence |
| 18354498 |
Mediation of eIF3-f polyubiquitination by the SCFMAFbx. The association of MAFbx with the essential Skp1, Roc 1 and Cul1 proteins, specific components of an E3 ubiquitin–protein ligase (SCFMAFbx), was previously described. Here, we present evidence that during muscle atrophy MAFbx targets the eukaryotic initiation factor 3 subunit 5 (eIF3-f) for ubiquitination and degradation by the proteasome. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
FBXO33 | up-regulates activity 
binding
|
SCF-betaTRCP |
0.475 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-271605 |
|
|
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 16797541 |
Here we identify FBX33 as a component of an SCF E3-ubiquitin ligase that targets the multifunctional regulator Y-box binding protein 1 (YB-1)/dbpB/p50 for polyubiquitination and destruction by the proteasome. By targeting YB-1 for proteasomal degradation, FBX33 negatively interferes with YB-1 mediated functions. FBX33 recruits Skp-1/Cul1 to YB-1 |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
FBXO33 | up-regulates activity
binding
|
Cullin 1-RBX1-Skp1 |
0.428 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-271769 |
|
|
Mus musculus |
C2C12 Cell |
| pmid |
sentence |
| 18354498 |
Mediation of eIF3-f polyubiquitination by the SCFMAFbx. The association of MAFbx with the essential Skp1, Roc 1 and Cul1 proteins, specific components of an E3 ubiquitin–protein ligase (SCFMAFbx), was previously described. Here, we present evidence that during muscle atrophy MAFbx targets the eukaryotic initiation factor 3 subunit 5 (eIF3-f) for ubiquitination and degradation by the proteasome. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
FBXO33 | down-regulates quantity by destabilization
binding
|
YBX1 |
0.39 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-271604 |
|
|
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 16797541 |
Here we identify FBX33 as a component of an SCF E3-ubiquitin ligase that targets the multifunctional regulator Y-box binding protein 1 (YB-1)/dbpB/p50 for polyubiquitination and destruction by the proteasome. By targeting YB-1 for proteasomal degradation, FBX33 negatively interferes with YB-1 mediated functions. FBX33 recruits Skp-1/Cul1 to YB-1 |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
3.0
FBXO33
- 
- 