| + |
NLRX1 | down-regulates activity 
binding
|
TRAF6 |
0.484 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-260364 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 21703539 |
Immunoprecipitation experiments showed that NLRX1 interacted with TRAF6 and TRAF3, but not with TRAF2 or TRAF5. These results further suggest that NLRX1 specifically inhibits TLR-induced TRAF6-dependent NF-kB signaling through targeting TRAF6. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
NLRX1 | down-regulates activity
binding
|
MAVS |
0.745 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-260357 |
|
|
Homo sapiens |
HeLa Cell, HEK-293T Cell |
| pmid |
sentence |
| 18200010 |
Here we describe human NLRX1, a highly conserved nucleotide-binding domain (NBD)- and leucine-rich-repeat (LRR)-containing family member (known as NLR) that localizes to the mitochondrial outer membrane and interacts with MAVS. Expression of NLRX1 results in the potent inhibition of RLH- and MAVS-mediated interferon-beta promoter activity and in the disruption of virus-induced RLH-MAVS interactions. Co-immunoprecipitation studies demonstrate that HA–NLRX1 interacts with MAVS but not with other known mitochondrial outer membrane proteins (BCL2 and BCL2L1), indicating specificity of the NLRX1–MAVS interaction. Finally, endogenous NLRX1 associates strongly with endogenous MAVS after immunoprecipitation with two different MAVS antibodies |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
NLRX1 | up-regulates activity 
binding
|
PCBP2 |
0.411 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-260359 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 28956771 |
Moreover, poly(rC) binding protein 2 (PCBP2) interacts with NLRX1 to participate in the NLRX1-induced degradation of MAVS and the inhibition of antiviral responses during HCV infection. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
NLRX1 | up-regulates activity 
relocalization
|
RELA |
0.262 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-260358 |
|
|
Homo sapiens |
HEK-293T Cell |
| pmid |
sentence |
| 18219313 |
NLRX1 synergistically potentiated ROS production induced by tumour necrosis factor alpha, Shigella infection and double-stranded RNA, resulting in amplified NF-kappaB-dependent and JUN amino-terminal kinases-dependent signalling. We observed that NLRX1-positive cells showed increased p65 translocation as early as 15 min after infection, an effect that was maintained over time. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
NLRX1 | up-regulates activity
relocalization
|
NfKb-p65/p50 |
0.274 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-260399 |
|
|
Homo sapiens |
HEK-293T Cell |
| pmid |
sentence |
| 18219313 |
NLRX1 synergistically potentiated ROS production induced by tumour necrosis factor alpha, Shigella infection and double-stranded RNA, resulting in amplified NF-kappaB-dependent and JUN amino-terminal kinases-dependent signalling. We observed that NLRX1-positive cells showed increased p65 translocation as early as 15 min after infection, an effect that was maintained over time. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
3.0
NLRX1
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