3.0
Summary
| Name |  FBXO11View Modifications |
| Full Name | F-box only protein 11 |
| Synonyms | Protein arginine N-methyltransferase 9, Vitiligo-associated protein 1, VIT-1 | FBX11, PRMT9, VIT1 |
| Primary ID | Q86XK2 |
| Links |  -  -  |
| Type | protein |
| Relations | 4 |
| Function | Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins, such as DTL/CDT2, BCL6 and PRDM1/BLIMP1. The SCF(FBXO11) complex mediates ubiquitination and degradation of BCL6, thereby playing a role in the germinal center B-cells terminal differentiation toward memory B-cells and plasma cells. The SCF(FBXO11) complex also mediates ubiquitination and degradation of DTL, an important step for the regulation of TGF-beta signaling, cell migration and the timing of the cell-cycle progression and exit. Binds to and neddylates phosphorylated p53/TP53, inhibiting its transcriptional activity. SCF(FBXO11) does not seem to direct ubiquitination of p53/TP53. |
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Modifications Tables
Relations
| Regulator | Mechanism | target | score ℹ | |
|---|---|---|---|---|
| + | FBXO11 | down-regulates 
neddylation
|
TP53 | 0.656 |
| Publications: | 2 | Organism: | Homo Sapiens | |
| + | FBXO11 | down-regulates
binding
|
DTL | 0.567 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | FBXO11 | down-regulates
binding
|
BCL6 | 0.508 |
| Publications: | 1 | Organism: | Homo Sapiens | |