| + |
EGFR | down-regulates activity 
phosphorylation
|
CCDC50 |
0.425 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-262850 |
Tyr217 |
MAEEKKAyKKAKERE |
Homo sapiens |
HeLa Cell |
| pmid |
sentence |
| 19059208 |
We also detected tyrosine phosphorylation of Ymer by EGF stimulation as previously reported (Fig. 1A). Furthermore, we verified that EGF receptor-mediated tyrosine phosphorylation of Ymer is inhibited by AG1478, which is known as an EGF receptor tyrosine kinase inhibitor (Fig. 1B). A luciferase reporter assay showed that mutation of tyrosines on Ymer (YmerY217/279/304F) results in loss of the inhibitory activity for NF-kappaB signaling. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-262851 |
Tyr279 |
TDGEDADyTHFTNQQ |
Homo sapiens |
HeLa Cell |
| pmid |
sentence |
| 19059208 |
We also detected tyrosine phosphorylation of Ymer by EGF stimulation as previously reported (Fig. 1A). Furthermore, we verified that EGF receptor-mediated tyrosine phosphorylation of Ymer is inhibited by AG1478, which is known as an EGF receptor tyrosine kinase inhibitor (Fig. 1B). A luciferase reporter assay showed that mutation of tyrosines on Ymer (YmerY217/279/304F) results in loss of the inhibitory activity for NF-kappaB signaling. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-262852 |
Tyr304 |
SSHKGFHyKH |
Homo sapiens |
HeLa Cell |
| pmid |
sentence |
| 19059208 |
We also detected tyrosine phosphorylation of Ymer by EGF stimulation as previously reported (Fig. 1A). Furthermore, we verified that EGF receptor-mediated tyrosine phosphorylation of Ymer is inhibited by AG1478, which is known as an EGF receptor tyrosine kinase inhibitor (Fig. 1B). A luciferase reporter assay showed that mutation of tyrosines on Ymer (YmerY217/279/304F) results in loss of the inhibitory activity for NF-kappaB signaling. |
|
| Publications: |
3 |
Organism: |
Homo Sapiens |
| + |
LCK | down-regulates activity
phosphorylation
|
CCDC50 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-262853 |
Tyr217 |
MAEEKKAyKKAKERE |
Homo sapiens |
|
| pmid |
sentence |
| 19059208 |
We found that Ymer was considerably phosphorylated on tyrosine residues also via Src family kinases such as Lck. A luciferase reporter assay showed that mutation of tyrosines on Ymer (YmerY217/279/304F) results in loss of the inhibitory activity for NF-kappaB signaling. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-262854 |
Tyr279 |
TDGEDADyTHFTNQQ |
Homo sapiens |
HeLa Cell |
| pmid |
sentence |
| 19059208 |
We found that Ymer was considerably phosphorylated on tyrosine residues also via Src family kinases such as Lck. A luciferase reporter assay showed that mutation of tyrosines on Ymer (YmerY217/279/304F) results in loss of the inhibitory activity for NF-kappaB signaling. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-262855 |
Tyr304 |
SSHKGFHyKH |
Homo sapiens |
HeLa Cell |
| pmid |
sentence |
| 19059208 |
We found that Ymer was considerably phosphorylated on tyrosine residues also via Src family kinases such as Lck. A luciferase reporter assay showed that mutation of tyrosines on Ymer (YmerY217/279/304F) results in loss of the inhibitory activity for NF-kappaB signaling. |
|
| Publications: |
3 |
Organism: |
Homo Sapiens |
3.0
CCDC50
- 
- 