| + |
NME1 | down-regulates 
phosphorylation
|
KSR1 |
0.543 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-90390 |
Ser406 |
TRLRRTEsVPSDINN |
Homo sapiens |
|
| pmid |
sentence |
| 12105213 |
Autophosphorylated recombinant nm23-h1 phosphorylated ksr in vitro. Using site-directed mutagenesis, we found that nm23-h1 phosphorylated ksr serine 392, a 14-3-3-binding site, consistent with the recent identification of c-tak1 as a kinase for this site. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
MAP3K7 | down-regulates
phosphorylation
|
KSR1 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-112779 |
Ser406 |
TRLRRTEsVPSDINN |
Homo sapiens |
|
| pmid |
sentence |
| 11741534 |
C-tak1 constitutively associates with mammalian ksr1 and phosphorylates serine 392 to confer 14-3-3 binding and cytoplasmic sequestration of ksr1 in unstimulated cells. In response to signal activation, the phosphorylation state of s392 is reduced, allowing the ksr1 complex to colocalize with activated ras and raf-1 at the plasma membrane |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
NME1 |
phosphorylation
|
KSR1 |
0.543 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-250299 |
Ser406 |
TRLRRTEsVPSDINN |
in vitro |
|
| pmid |
sentence |
| 12105213 |
Mutation of Ser392 to alanine consistently reduced Nm23-H1 phosphorylation, confirming it as a site of Nm23-H1 kinase activity The unique phosphorylation pattern of KSR by Nm23-H1 will be the subject of further investigation to determine its effects on KSR protein binding, subcellular localization, response to various signals, etc. |
|
| Publications: |
1 |
Organism: |
In Vitro |
| + |
MARK3 | down-regulates activity
phosphorylation
|
KSR1 |
0.642 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-279225 |
Ser406 |
TRLRRTEsVPSDINN |
Homo sapiens |
|
| pmid |
sentence |
| 22206009 |
C-TAK1 phosphorylates KSR1 at S392, forming a 14-3-3 binding site.|In mammalian cells, C-TAK1 has been shown to negatively regulate KSR1 by phosphorylation of Ser392. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
MARK2 | down-regulates activity
phosphorylation
|
KSR1 |
0.315 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-279343 |
Ser406 |
TRLRRTEsVPSDINN |
Homo sapiens |
|
| pmid |
sentence |
| 22206009 |
In vivo, MARK2 appears to negatively regulate KSR1 in insulin sensitivity.|These data suggest that MARK2 phosphorylates KSR1 on Ser392, which has been shown previously to function as a negative regulatory site xref . |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
KSR1 | up-regulates 
phosphorylation
|
RAF1 |
0.653 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-85386 |
Thr269 |
NVHMVSTtLPVDSRM |
Homo sapiens |
|
| pmid |
sentence |
| 11134016 |
Here we show that phosphorylation of c-raf-1 on thr(269) by ksr is necessary for optimal activation in response to egf stimulation. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
KSR1 | up-regulates activity
binding
|
ARAF |
0.567 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-273876 |
|
|
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 29433126 |
In mammals, RAF family kinases include three catalytically competent enzymes (ARAF, BRAF and CRAF) and two pseudokinases (KSR1 and KSR2) that have been described as scaffolds owing to their apparent ability to bridge RAF isoforms and their substrate, mitogen-activated protein kinase kinase (MEK).Kinase suppressor of Ras (KSR) pseudokinases were also shown to dimerize with kinase-competent RAFs to stimulate catalysis allosterically. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
KSR1 | up-regulates activity
binding
|
BRAF |
0.63 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-273878 |
|
|
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 29433126 |
In mammals, RAF family kinases include three catalytically competent enzymes (ARAF, BRAF and CRAF) and two pseudokinases (KSR1 and KSR2) that have been described as scaffolds owing to their apparent ability to bridge RAF isoforms and their substrate, mitogen-activated protein kinase kinase (MEK).Kinase suppressor of Ras (KSR) pseudokinases were also shown to dimerize with kinase-competent RAFs to stimulate catalysis allosterically. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
KSR1 | up-regulates activity
binding
|
RAF1 |
0.653 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-273880 |
|
|
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 29433126 |
In mammals, RAF family kinases include three catalytically competent enzymes (ARAF, BRAF and CRAF) and two pseudokinases (KSR1 and KSR2) that have been described as scaffolds owing to their apparent ability to bridge RAF isoforms and their substrate, mitogen-activated protein kinase kinase (MEK).Kinase suppressor of Ras (KSR) pseudokinases were also shown to dimerize with kinase-competent RAFs to stimulate catalysis allosterically. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
BRAP | down-regulates quantity by destabilization
ubiquitination
|
KSR1 |
0.66 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-272028 |
|
|
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 23105109 |
Here we report on a novel interaction between the E3 ligase BRAP (also referred to as IMP), a negative regulator of the MAPK scaffold protein KSR, and two closely related deubiquitylases, USP15 and USP4. USP15 as well as USP4 oppose the autoubiquitylation of BRAP, whereas BRAP promotes the ubiquitylation of USP15. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
3.0
KSR1
- 
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