4.0
Summary
| Name |  NELFCDView Modifications |
| Full Name | Negative elongation factor C/D |
| Synonyms | NELF-C/D, TH1-like protein | NELFD, TH1, TH1L |
| Primary ID | Q8IXH7 |
| Links |  -  -  |
| Type | protein |
| Relations | 3 |
| Function | Essential component of the NELF complex, a complex that negatively regulates the elongation of transcription by RNA polymerase II (PubMed:12612062). The NELF complex, which acts via an association with the DSIF complex and causes transcriptional pausing, is counteracted by the P-TEFb kinase complex (PubMed:10199401). |
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Modifications Tables
Relations
| Regulator | Mechanism | target | score ℹ | |
|---|---|---|---|---|
| + | SRC | down-regulates activity 
phosphorylation
|
NELFCD | 0.337 |
| Publications: | 1 | Organism: | Chlorocebus Aethiops | |
| + | UBE3A | down-regulates quantity by destabilization
ubiquitination
|
NELFCD | 0.325 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | NELFCD | form complex 
binding
|
NELF | 0.861 |
| Publications: | 1 | Organism: | Homo Sapiens | |