3.0
Summary
| Name |  MICU2
|
| Full Name | Calcium uptake protein 2, mitochondrial |
| Synonyms | EF-hand domain-containing family member A1 | EFHA1 |
| Primary ID | Q8IYU8 |
| Links |  -  -  |
| Type | protein |
| Relations | 2 |
| Function | Key regulator of mitochondrial calcium uniporter (MCU) required to limit calcium uptake by MCU when cytoplasmic calcium is low (PubMed:24503055, PubMed:24560927, PubMed:26903221). MICU1 and MICU2 form a disulfide-linked heterodimer that stimulate and inhibit MCU activity, depending on the concentration of calcium (PubMed:24560927). MICU2 acts as a gatekeeper of MCU that senses calcium level via its EF-hand domains: prevents channel opening at resting calcium, avoiding energy dissipation and cell-death triggering (PubMed:24560927). |
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Relations
| Regulator | Mechanism | target | score ℹ | |
|---|---|---|---|---|
| + | MICU2 | form complex 
binding
|
MCU_MICUB_variant | 0.645 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | MICU2 | form complex
binding
|
MCU_MICU2_variant | 0.645 |
| Publications: | 1 | Organism: | Homo Sapiens | |