Summary

Name ARHGEF28
Full Name Rho guanine nucleotide exchange factor 28
Synonyms 190 kDa guanine nucleotide exchange factor, p190-RhoGEF, p190RhoGEF, Rho guanine nucleotide exchange factor | KIAA1998, RGNEF
Primary ID Q8N1W1
Links - -
Type protein
Relations 3
Function Functions as a RHOA-specific guanine nucleotide exchange factor regulating signaling pathways downstream of integrins and growth factor receptors. Functions in axonal branching, synapse formation and dendritic morphogenesis. Functions also in focal adhesion formation, cell motility and B-lymphocytes activation. May regulate NEFL expression and aggregation and play a role in apoptosis (By similarity).

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Relations

Regulator Mechanism target score ℹ
+ GNAQup-regulates activity img/direct-activation.png binding ARHGEF28 0.293
Publications: 1 Organism: Homo Sapiens
+ GNA13up-regulates activity img/direct-activation.png binding ARHGEF28 0.342
Publications: 1 Organism: Homo Sapiens
+ ARHGEF28up-regulates activity img/direct-activation.png guanine nucleotide exchange factor RHOA 0.754
Publications: 1 Organism: Homo Sapiens