3.0
Summary
| Name |  SIRT6View Modifications |
| Full Name | NAD-dependent protein deacetylase sirtuin-6 |
| Synonyms | Regulatory protein SIR2 homolog 6, SIR2-like protein 6 | SIR2L6 |
| Primary ID | Q8N6T7 |
| Links |  -  -  |
| Type | protein |
| Relations | 6 |
| Pathways | Circadian clock |
| Function | NAD-dependent protein deacetylase. Has deacetylase activity towards histone H3K9Ac and H3K56Ac. Modulates acetylation of histone H3 in telomeric chromatin during the S-phase of the cell cycle. Deacetylates histone H3K9Ac at NF-kappa-B target promoters and may down-regulate the expression of a subset of NF-kappa-B target genes. Acts as a corepressor of the transcription factor HIF1A to control the expression of multiple glycolytic genes to regulate glucose homeostasis. Required for genomic stability. Regulates the production of TNF protein. Has a role in the regulation of life span (By similarity). Deacetylation of nucleosomes interferes with RELA binding to target DNA. May be required for the association of WRN with telomeres during S-phase and for normal telomere maintenance. Required for genomic stability. Required for normal IGF1 serum levels and normal glucose homeostasis. Modulates cellular senescence and apoptosis. On DNA damage, promotes DNA end resection via deacetylation of RBBP8. Has very weak deacetylase activity and can bind NAD(+) in the absence of acetylated substrate. |
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Modifications Tables
Relations
| Regulator | Mechanism | target | score ℹ | |
|---|---|---|---|---|
| + | SIRT6 | up-regulates 
deacetylation
|
TNF | 0.321 |
| Publications: | 2 | Organism: | Homo Sapiens | |
| + | SIRT6 | down-regulates activity 
deacetylation
|
ME1 | 0.253 |
| Publications: | 1 | |||
| + | SIRT6 | up-regulates activity
binding
|
CLOCK/BMAL1 | 0.377 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| Pathways: | Circadian clock | |||
| + | SIRT6 | up-regulates activity
binding
|
SREBF1 | 0.38 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| Pathways: | Circadian clock | |||
| + | Fatty acid | up-regulates
|
SIRT6 | 0.7 |
| Publications: | 1 | Organism: | Homo Sapiens | |