| + |
SAMD12 | down-regulates quantity by destabilization 
binding
|
CNKSR2 |
0.355 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-282691 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 40010432 |
SAMD12 inhibits CNKSR2-mediated TNIK membrane association and activation. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Tissue: |
Neuron |
| + |
SAMD12 | down-regulates quantity by destabilization
binding
|
CNKSR1 |
0.296 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-282685 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 40010432 |
In this study, we characterized the interaction mechanisms between MAP4K kinases (MAP4K4, MINK1 and TNIK) and the CNKSR1/2/3 scaffold proteins, and discovered that SAMD12, a familial adult myoclonic epilepsy disease gene product, or its close homolog SAMD10, binds to CNKSR1/2/3 with exceptionally strong affinities and can quantitatively displace MAP4K from CNKSR1/2/3 scaffolds. The CNK family proteins are evolutionarily conserved scaffold proteins. Three CNK paralogs, CNKSR1, CNKSR2 and CNKSR3, are expressed in mammals.The CNKSR family proteins interact with SAMDs and MAP4Ks. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Tissue: |
Neuron |
| + |
SAMD12 | down-regulates quantity by destabilization
binding
|
CNKSR3 |
0.296 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-282686 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 40010432 |
In this study, we characterized the interaction mechanisms between MAP4K kinases (MAP4K4, MINK1 and TNIK) and the CNKSR1/2/3 scaffold proteins, and discovered that SAMD12, a familial adult myoclonic epilepsy disease gene product, or its close homolog SAMD10, binds to CNKSR1/2/3 with exceptionally strong affinities and can quantitatively displace MAP4K from CNKSR1/2/3 scaffolds. The CNK family proteins are evolutionarily conserved scaffold proteins. Three CNK paralogs, CNKSR1, CNKSR2 and CNKSR3, are expressed in mammals.The CNKSR family proteins interact with SAMDs and MAP4Ks. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Tissue: |
Neuron |
4.0
SAMD12
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