| + |
CNKSR2 | up-regulates 
binding
|
RAF1 |
0.777 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-119039 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 14597674 |
We show cnk2 interacts with raf. cnk2 interacts with the gef domain of rlf and with both the regulatory and catalytic domains of raf. The raf interaction was also mapped to the carboxyl-terminal half of cnk2. Overexpression of cnk2 results in inhibition of the mapk signaling pathway. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
CNKSR2 | up-regulates quantity by stabilization
binding
|
MAP4K4 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-282683 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 40010432 |
In this study, we characterized the interaction mechanisms between MAP4K kinases (MAP4K4, MINK1 and TNIK) and the CNKSR1/2/3 scaffold proteins, and discovered that SAMD12, a familial adult myoclonic epilepsy disease gene product, or its close homolog SAMD10, binds to CNKSR1/2/3 with exceptionally strong affinities and can quantitatively displace MAP4K from CNKSR1/2/3 scaffolds. The CNK family proteins are evolutionarily conserved scaffold proteins. Three CNK paralogs, CNKSR1, CNKSR2 and CNKSR3, are expressed in mammals.The CNKSR family proteins interact with SAMDs and MAP4Ks. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Tissue: |
Neuron |
| + |
SAMD10 | down-regulates quantity by destabilization 
binding
|
CNKSR2 |
0.268 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-282688 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 40010432 |
In this study, we characterized the interaction mechanisms between MAP4K kinases (MAP4K4, MINK1 and TNIK) and the CNKSR1/2/3 scaffold proteins, and discovered that SAMD12, a familial adult myoclonic epilepsy disease gene product, or its close homolog SAMD10, binds to CNKSR1/2/3 with exceptionally strong affinities and can quantitatively displace MAP4K from CNKSR1/2/3 scaffolds. The CNK family proteins are evolutionarily conserved scaffold proteins. Three CNK paralogs, CNKSR1, CNKSR2 and CNKSR3, are expressed in mammals.The CNKSR family proteins interact with SAMDs and MAP4Ks. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Tissue: |
Neuron |
| + |
CNKSR2 | up-regulates activity
binding
|
TNIK |
0.264 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-282690 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 40010432 |
CNKSR2 acts as both a scaffold and an activator of TNIK during neuronal synapse development. SAMD12 inhibits CNKSR2-mediated TNIK membrane association and activation. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Tissue: |
Neuron |
| + |
SAMD12 | down-regulates quantity by destabilization
binding
|
CNKSR2 |
0.355 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-282691 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 40010432 |
SAMD12 inhibits CNKSR2-mediated TNIK membrane association and activation. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Tissue: |
Neuron |
| + |
CNKSR2 | up-regulates quantity by stabilization
binding
|
MINK1 |
0.246 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-282680 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 40010432 |
In this study, we characterized the interaction mechanisms between MAP4K kinases (MAP4K4, MINK1 and TNIK) and the CNKSR1/2/3 scaffold proteins, and discovered that SAMD12, a familial adult myoclonic epilepsy disease gene product, or its close homolog SAMD10, binds to CNKSR1/2/3 with exceptionally strong affinities and can quantitatively displace MAP4K from CNKSR1/2/3 scaffolds. The CNK family proteins are evolutionarily conserved scaffold proteins. Three CNK paralogs, CNKSR1, CNKSR2 and CNKSR3, are expressed in mammals.The CNKSR family proteins interact with SAMDs and MAP4Ks. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Tissue: |
Neuron |
4.0
CNKSR2
- 
- 