| + |
PLPPR1 | up-regulates activity 
binding
|
RASGEF1A |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-261807 |
|
|
Homo sapiens |
U-87MG Cell |
| pmid |
sentence |
| 27058420 |
Oncogenic effects of imbalanced PRG3 are mediated via PRG3-RasGEF1 interaction and Ras activation. PRG3 interacts with RasGEF1 in vivo.We could further show that PRG3 executes the binding to RasGEF1 predominantly via its C-terminal domain (CT) and in the consequence causes Ras activation. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
RASGEF1A | up-regulates
guanine nucleotide exchange factor
|
KRAS |
0.402 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-183826 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 19201597 |
Gefs catalyse the transition from gdp-bound, inactive ras to gtp-bound, active ras. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
RASGEF1A | up-regulates
binding
|
HRAS |
0.411 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-183823 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 19201597 |
Gefs catalyse the transition from gdp-bound, inactive ras to gtp-bound, active ras. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
RASGEF1A | up-regulates
binding
|
NRAS |
0.357 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-183829 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 19201597 |
Gefs catalyse the transition from gdp-bound, inactive ras to gtp-bound, active ras. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
3.0
RASGEF1A
- 
- 