| + |
SREBF2 | up-regulates quantity by expression 
transcriptional regulation
|
PCSK9 |
0.48 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-255223 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 17921436 |
Expression of nuclear forms of sterol-regulatory element binding protein-1 (SREBP-1) and SREBP-2 dramatically increased the promoter activity of PCSK9. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254459 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 21123766 |
Recent studies have demonstrated that PCSK9 mRNA expression was upregulated to a greater extent than that of the LDL receptor in human hepatocytes in primary culture. Our findings also support the role of SREBP-2 as a transcriptional regulator of both the LDL receptor and PCSK9 in human enterocytes. |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| + |
SREBF1 | up-regulates quantity by expression
transcriptional regulation
|
PCSK9 |
0.44 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-255222 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 17921436 |
Expression of nuclear forms of sterol-regulatory element binding protein-1 (SREBP-1) and SREBP-2 dramatically increased the promoter activity of PCSK9. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
HNF4A | up-regulates quantity by expression 
transcriptional regulation
|
PCSK9 |
0.271 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254451 |
|
|
Homo sapiens |
Enterocyte |
| pmid |
sentence |
| 21123766 |
Recent studies have demonstrated that PCSK9 mRNA expression was upregulated to a greater extent than that of the LDL receptor in human hepatocytes in primary culture. Our findings also support the role of SREBP-2 as a transcriptional regulator of both the LDL receptor and PCSK9 in human enterocytes. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
3.0
PCSK9
- 
- 