Relation Results

Summary

Name FAM20C
Full Name Extracellular serine/threonine protein kinase FAM20C
Synonyms Dentin matrix protein 4, DMP-4, Golgi casein kinase, Golgi-enriched fraction casein kinase, GEF-CK | DMP4
Primary ID Q8IXL6
Links - -
Type protein
Relations 4
Function Golgi serine/threonine protein kinase that phosphorylates secretory pathway proteins within Ser-x-Glu/pSer motifs and plays a key role in biomineraliz ...
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Type: Score: Layout: SPV 
0.20.6370.3790.397FAM20CERO1AFGF23P4HBHRC

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▶Modifications Tables

Relations
Regulator
Mechanism
target
score ℹ
+ FAM20Cup-regulates activity img/direct-activation.png phosphorylation ERO1A 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-277395 Ser145 GAVDESLsEETQKAV Homo sapiens HeLa Cell
pmid sentence
We further show that ER oxidoreductin 1α (Ero1α), the pivotal sulfhydryl oxidase that catalyzes disulfide formation in the ER, is phosphorylated by Fam20C in the Golgi apparatus and retrograde-transported to the ER mediated by ERp44. The phosphorylation of Ser145 greatly enhances Ero1α oxidase activity and is critical for maintaining ER redox homeostasis and promoting oxidative protein folding.
Publications: 1 Organism: Homo Sapiens
+ FAM20Cdown-regulates activity img/direct_inhibition.png phosphorylation FGF23 0.637
Identifier Residue Sequence Organism Cell Line
SIGNOR-260925 Ser180 IPRRHTRsAEDDSER Homo sapiens
pmid sentence
Here we show that Fam20C directly phosphorylates FGF23 on Ser(180) | Our above results support, phosphorylation of FGF23 at Ser180 inhibits O-glycosylation and would therefore promote hormone proteolysis and thus inactivation. 
Publications: 1 Organism: Homo Sapiens
+ FAM20Cup-regulates activity img/direct-activation.png phosphorylation P4HB 0.379
Identifier Residue Sequence Organism Cell Line
SIGNOR-275574 Ser357 KIKPHLMsQELPEDW
pmid sentence
The secretory pathway kinase Fam20C phosphorylates Ser357 of PDI and responds rapidly to various ER stressors. Phosphorylation of Ser357 induces an open conformation of PDI and turns it from a "foldase" into a "holdase", which is critical for preventing protein misfolding in the ER. Phosphorylated PDI also binds to the lumenal domain of IRE1α, a major UPR signal transducer, and attenuates excessive IRE1α activity.
Publications: 1
+ FAM20Cup-regulates activity img/direct-activation.png phosphorylation HRC 0.397
Identifier Residue Sequence Organism Cell Line
SIGNOR-273639 Ser96 EKEDEDVsKEYGHLL Rattus norvegicus H9c2 Cell
pmid sentence
Here, we demonstrate that family with sequence similarity 20C (Fam20C), a recently characterized protein kinase in the secretory pathway, phosphorylates HRC on Ser96. HRC Ser96 phosphorylation was confirmed in cells and human hearts.The pSer96-HRC binds tighter to triadin than S96A-HRC, which cannot be phosphorylated. Conversely, S96A-HRC or unphosphorylated Ser96-HRC binds tighter to SERCA2a. This suggests that Ser96-HRC phosphorylation (P) regulates HRC’s interactions with the major SR Ca-cycling proteins.
Publications: 1 Organism: Rattus Norvegicus
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