3.0
Summary
| Name |  FAM20CView Modifications |
| Full Name | Extracellular serine/threonine protein kinase FAM20C |
| Synonyms | Dentin matrix protein 4, DMP-4, Golgi casein kinase, Golgi-enriched fraction casein kinase, GEF-CK | DMP4 |
| Primary ID | Q8IXL6 |
| Links |  -  -  |
| Type | protein |
| Relations | 9 |
| Function | Golgi serine/threonine protein kinase that phosphorylates secretory pathway proteins within Ser-x-Glu/pSer motifs and plays a key role in biomineralization of bones and teeth (PubMed:22582013, PubMed:23754375, PubMed:25789606). Constitutes the main protein kinase for extracellular proteins, generating the majority of the extracellular phosphoproteome (PubMed:26091039). Mainly phosphorylates proteins within the Ser-x-Glu/pSer motif, but also displays a broader substrate specificity (PubMed:26091039). Phosphorylates casein as well as a number of proteins involved in biomineralization such as AMELX, AMTN, ENAM and SPP1 (PubMed:22582013, PubMed:25789606). In addition to its role in biomineralization, also plays a role in lipid homeostasis, wound healing and cell migration and adhesion (PubMed:26091039). |
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Modifications Tables
Relations
| Regulator | Mechanism | target | score ℹ | |
|---|---|---|---|---|
| + | FAM20C | up-regulates activity 
phosphorylation
|
ERO1A | 0.2 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | FAM20C | down-regulates activity 
phosphorylation
|
FGF23 | 0.637 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | FAM20C | up-regulates activity
phosphorylation
|
P4HB | 0.386 |
| Publications: | 1 | |||
| + | FAM20C | up-regulates activity
phosphorylation
|
PCSK9 | 0.536 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | FAM20C | up-regulates activity
phosphorylation
|
STIM1 | 0.2 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | FAM20C | up-regulates activity
phosphorylation
|
HRC | 0.403 |
| Publications: | 1 | Organism: | Rattus Norvegicus | |
| + | FAM20C | up-regulates activity
phosphorylation
|
VWF | 0.2 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | FAM20C | up-regulates activity
phosphorylation
|
SDF4 | 0.2 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | FAM20C | down-regulates quantity
phosphorylation
|
SPP1 | 0.682 |
| Publications: | 1 | Organism: | Homo Sapiens | |