Summary

Name HSD17B11
Full Name Estradiol 17-beta-dehydrogenase 11
Synonyms 17-beta-hydroxysteroid dehydrogenase 11, 17-beta-HSD 11, 17bHSD11, 17betaHSD11, 17-beta-hydroxysteroid dehydrogenase XI, 17-beta-HSD XI, 17betaHSDXI, Cutaneous T-cell lymphoma-associated antigen HD-CL-03, CTCL-associated antigen HD-CL-03, Dehydrogenase/reductase SDR family member 8, Retinal short-chain dehydrogenase/reductase 2, retSDR2, Short chain dehydrogenase/reductase family 16C member 2 | DHRS8, PAN1B, SDR16C2
Primary ID Q8NBQ5
Links - -
Type protein
Relations 4
Pathways Sex Hormone Biosynthesis
Function Can convert androstan-3-alpha,17-beta-diol (3-alpha-diol) to androsterone in vitro, suggesting that it may participate in androgen metabolism during steroidogenesis. May act by metabolizing compounds that stimulate steroid synthesis and/or by generating metabolites that inhibit it. Has no activity toward DHEA (dehydroepiandrosterone), or A-dione (4-androste-3,17-dione), and only a slight activity toward testosterone to A-dione. Tumor-associated antigen in cutaneous T-cell lymphoma.

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Relations

Regulator Mechanism target score ℹ
+ HSD17B11up-regulates quantity img/direct-activation.png chemical modification testosterone 0.8
Publications: 1 Organism: Homo Sapiens
Tissue: Zona Reticulata
Pathways:Sex Hormone Biosynthesis
+ HSD17B11up-regulates quantity img/direct-activation.png chemical modification 17beta-estradiol 0.8
Publications: 1 Organism: Homo Sapiens
Tissue: Zona Reticulata
Pathways:Sex Hormone Biosynthesis
+ HSD17B11up-regulates quantity img/direct-activation.png chemical modification estrone 0.8
Publications: 1 Organism: Homo Sapiens
Tissue: Zona Reticulata
Pathways:Sex Hormone Biosynthesis
+ HSD17B11up-regulates quantity img/direct-activation.png chemical modification androst-5-ene-3beta,17beta-diol 0.8
Publications: 1 Organism: Homo Sapiens
Tissue: Testis
Pathways:Sex Hormone Biosynthesis